science

SKF-81,297

SKF-81,297 is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand SKF-81,297 rather than just read about it. In short: SKF-81,297 is a dopamine D1-like receptor agonist and stimulant-like drug of the 3-benzazepine family which was under development for the treatment of Parkinson's disease but was never marketed. It is a cyclized phenethylamine and catecholamine and is a modified derivative of the monoamine neurotransmitter dopamine.

Key takeaways

SKF-81,297 belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect SKF-81,297 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of SKF-81,297 from memory before moving on to harder problems.

Reference excerpt

SKF-81,297 is a dopamine D1-like receptor agonist and stimulant-like drug of the 3-benzazepine family which was under development for the treatment of Parkinson's disease but was never marketed. It is a cyclized phenethylamine and catecholamine and is a modified derivative of the monoamine neurotransmitter dopamine. The drug is taken orally. The drug acts as a selective dopamine D1 and D5 receptor full agonist. In addition, it acts as a partial agonist at dopamine D1–D2 receptor heteromers. It produces a characteristic stimulant-like pattern of effects including anorexia, hyperactivity, and self-administration in animals. This profile is shared with several related drugs such as 6-Br-APB and SKF-82,958, but not with certain other dopamine D1 receptor full agonists such as A-77,636, reflecting functional selectivity of dopamine D1 receptor activation. The drug also produces pro-motivational effects in animals. Although it produces stimulant-like effects in animals, SKF-81,297 did not substitute for dextroamphetamine in rodent drug discrimination tests in multiple studies. This is in notable contrast to dopamine D2 receptor agonists like quinpirole and RU-24213, which fully substitute for dextroamphetamine in such tests. However, in another study, higher doses of SKF-81,297 were able to partially substitute for dextroamphetamine. SKF-81,297 readily crosses the blood–brain barrier in rodents and shows substantially greater penetration than the related dopamine D1-like receptor agonist SKF-38,393. Its predicted log P is 2.7. SKF-81,297 was first described in the scientific literature by 1988. It was developed by GlaxoSmithKline. The drug reached the preclinical research stage of development for Parkinson's disease prior to the discontinuation of its development. One of the patented uses for SKF-81,297 is as an augmentation agent when combined with an appropriate choice of an antidepressant.

See also Substituted 3-benzazepine Cyclized phenethylamine List of investigational Parkinson's disease drugs Motivation-enhancing drug

References

External links SKF-81297 - Isomer Design

Illustrations

Worked examples

Example 1 — a first encounter with SKF-81,297

Start with the simplest possible case. Write down what SKF-81,297 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to SKF-81,297 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about SKF-81,297 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of SKF-81,297

In research: SKF-81,297 appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses SKF-81,297 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: SKF-81,297 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, Abandoned drugs, Antiparkinsonian agents, so understanding it makes those chapters shorter.
In everyday life: Look for SKF-81,297 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study SKF-81,297 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what SKF-81,297 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain SKF-81,297 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is SKF-81,297 in simple terms?

Why does SKF-81,297 matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study SKF-81,297?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on SKF-81,297.