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SKF-83,959

SKF-83,959 is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand SKF-83,959 rather than just read about it. In short: SKF-83,959, a synthetic benzazepine derivative used in scientific research, acts as an agonist at the D1–D2 dopamine receptor heteromer. It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer.

SKF-83,959 — main illustration
SKF-83,959 — illustration

Key takeaways

  • SKF-83,959 belongs to science; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect SKF-83,959 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of SKF-83,959 from memory before moving on to harder problems.

Reference excerpt

SKF-83,959, a synthetic benzazepine derivative used in scientific research, acts as an agonist at the D1–D2 dopamine receptor heteromer. It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 additionally inhibits sodium channels as well as delayed rectifier potassium channels. SKF-83,959 is a racemate that consists of the R-(+)- and S-(−)-enantiomers MCL-202 and MCL-201, respectively. SKF-83,959 was described as a SNDRI. The synthesis has been described.

See also Substituted 3-benzazepine

References

Further reading Lee SM, Yang Y, Mailman RB (2014). "Dopamine D1 receptor signaling: Does GαQ-phospholipase C actually play a role?". J. Pharmacol. Exp. Ther. 351 (1): 9–17. doi:10.1124/jpet.114.214411. PMC 4165024. PMID 25052835. Lee SM, Kant A, Blake D, et al. (2014). "SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C". Neuropharmacology. 86: 145–54. doi:10.1016/j.neuropharm.2014.05.042. PMC 4188748. PMID 24929112.

Illustrations

SKF-83,959 illustration

Worked examples

Example 1 — a first encounter with SKF-83,959

Start with the simplest possible case. Write down what SKF-83,959 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to SKF-83,959 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about SKF-83,959 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of SKF-83,959

In research
SKF-83,959 appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses SKF-83,959 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
SKF-83,959 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, Catechols, Chloroarenes, so understanding it makes those chapters shorter.
In everyday life
Look for SKF-83,959 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study SKF-83,959 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what SKF-83,959 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain SKF-83,959 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is SKF-83,959 in simple terms?

SKF-83,959, a synthetic benzazepine derivative used in scientific research, acts as an agonist at the D1–D2 dopamine receptor heteromer. It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer.

Why does SKF-83,959 matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study SKF-83,959?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on SKF-83,959.

Tags

  • 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
  • Catechols
  • Chloroarenes
  • D1 receptor agonists
  • D2 receptor agonists
  • Drugs developed by GSK plc
  • Nervous system drug stubs
  • Potassium channel blockers
  • Receptor heteromer ligands
  • Sigma receptor modulators
  • Sodium channel blockers

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