biology

STK35L1

STK35L1 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand STK35L1 rather than just read about it. In short: STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene. It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome.

Key takeaways

STK35L1 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect STK35L1 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of STK35L1 from memory before moving on to harder problems.

Reference excerpt

STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene. It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells. Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

Functions STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.

References

Illustrations

Worked examples

Example 1 — a first encounter with STK35L1

Start with the simplest possible case. Write down what STK35L1 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to STK35L1 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about STK35L1 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of STK35L1

In research: STK35L1 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses STK35L1 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: STK35L1 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 20, Human chromosome 20 gene stubs, so understanding it makes those chapters shorter.
In everyday life: Look for STK35L1 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study STK35L1 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what STK35L1 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain STK35L1 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is STK35L1 in simple terms?

Why does STK35L1 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study STK35L1?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on STK35L1.