science

STS-135 (drug)

STS-135 (drug) is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand STS-135 (drug) rather than just read about it. In short: STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA and ACBM-2201) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.

Key takeaways

STS-135 (drug) belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect STS-135 (drug) to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of STS-135 (drug) from memory before moving on to harder problems.

Reference excerpt

STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA and ACBM-2201) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors. STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity. It was first detected in 2013.

Legal status As of October 2015 STS-135 is a controlled substance in China. It is also illegal in the UK.

Detection A forensic standard of STS-135 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.

See also AB-001 ADAMANTYL-THPINACA APICA APINACA AM-2201 JWH-018 UR-144 XLR-11

References

Illustrations

Worked examples

Example 1 — a first encounter with STS-135 (drug)

Start with the simplest possible case. Write down what STS-135 (drug) claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to STS-135 (drug) before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about STS-135 (drug) ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of STS-135 (drug)

In research: STS-135 (drug) appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses STS-135 (drug) in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: STS-135 (drug) is common in secondary-school and first-year university syllabi. It links to neighbouring topics Adamantanes, Cannabinoids, Designer drugs, so understanding it makes those chapters shorter.
In everyday life: Look for STS-135 (drug) outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study STS-135 (drug) in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what STS-135 (drug) means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain STS-135 (drug) out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is STS-135 (drug) in simple terms?

Why does STS-135 (drug) matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study STS-135 (drug)?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on STS-135 (drug).