Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene.
Function The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.