biology

Sally-Ann Poulsen

Sally-Ann Poulsen is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Sally-Ann Poulsen rather than just read about it. In short: Sally-Ann Poulsen is an Australian chemical biologist who is a Professor and Director at Griffith University. Her research considers medicinal chemistry and drug discovery.

Key takeaways

Sally-Ann Poulsen belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Sally-Ann Poulsen to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Sally-Ann Poulsen from memory before moving on to harder problems.

Reference excerpt

Sally-Ann Poulsen is an Australian chemical biologist who is a Professor and Director at Griffith University. Her research considers medicinal chemistry and drug discovery. She is Chair of the Royal Australian Chemical Institute Medicinal Chemistry and Chemical Biology Division.

Early life and education Poulsen grew up in a rural community in Australia. She attended a small primary school of only seventeen students and one teacher. She was the highest achieving student of her school. After completing high school, Poulsen got a job, and eventually decided to go to university. Poulsen was an undergraduate student at Griffith University, where she was a university medallist. She was the first member of her family to complete higher education. During her bachelor's degree she started to study pyrazolo [3,4-d] pyrimidines. As an undergraduate student, Poulsen was part of the National Youth Science Forum. Poulsen remained at Griffith University for her graduate studies, where she continued to study pyrimidines, looking for structure-function relationships in their binding to adenosine receptors. After earning her doctorate, Poulsen moved to the United Kingdom, where she was a postdoctoral researcher at the University of Cambridge and AstraZeneca. She proposed that adenosine receptors offered novel opportunities of drug design.

Research and career Poulsen returned to Australia, where she joined the University of Queensland as a Royal Society National Health and Medical Research Council research fellow. After ten months at Queensland, Poulsen returned to Griffith University as an Australian Research Council Queen Elizabeth Fellow. She was made an ARC Future Fellow in 2012, and promoted to Professor in 2014. Poulsen's research considers medicinal chemistry and drug discovery. She leads fragment-based lead discovery, which looks to identify potent compounds from fragments that weakly bind to targets. Amongst various medical conditions, Poulsen investigated drug resistant brain cancer. Such cancers are typically treated with temozolomide, but they can become resistant over time. Poulsen demonstrated that it is possible to reverse this resistance by blocking the proteins alongside pumps on the surface of glioblastoma cells, which allow the temozolomide to exit the glioblastoma before it reaches high enough levels to destroy the cancer. In March 2021 Poulsen was appointed Deputy Director of the Griffith Institute for Drug Discovery. She is an Associate Editor of MedChemComm.

Selected publications Alfonso Maresca; Claudia Temperini; Hoan Vu; Ngoc B Pham; Sally-Ann Poulsen; Andrea Scozzafava; Ronald J Quinn; Claudiu T Supuran (4 March 2009). "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors". Journal of the American Chemical Society. 131 (8): 3057–62. doi:10.1021/ja809683v. ISSN 0002-7863. PMID 19206230. Wikidata Q27653712. S A Poulsen; Ronald J. Quinn (1 June 1998). "Adenosine receptors: new opportunities for future drugs". Bioorganic & Medicinal Chemistry. 6 (6): 619–641. doi:10.1016/s0968-0896(98)00038-8. ISSN 0968-0896. PMID 9681130. Wikidata Q40849413. Sonia Del Prete; Daniela Vullo; Gillian M Fisher; Katherine T Andrews; Sally-Ann Poulsen; Clemente Capasso; Claudiu T Supuran (15 September 2014). "Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases". Bioorganic & Medicinal Chemistry Letters. 24 (18): 4389–96. doi:10.1016/j.bmcl.2014.08.015. ISSN 0960-894X. PMID 25168745. Wikidata Q27973368.

References

Worked examples

Example 1 — a first encounter with Sally-Ann Poulsen

Start with the simplest possible case. Write down what Sally-Ann Poulsen claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Sally-Ann Poulsen before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Sally-Ann Poulsen ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Sally-Ann Poulsen

In research: Sally-Ann Poulsen appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Sally-Ann Poulsen in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Sally-Ann Poulsen is common in secondary-school and first-year university syllabi. It links to neighbouring topics 21st-century Australian biologists, 21st-century Australian scientists, 21st-century Australian women scientists, so understanding it makes those chapters shorter.
In everyday life: Look for Sally-Ann Poulsen outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Sally-Ann Poulsen in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Sally-Ann Poulsen means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Sally-Ann Poulsen out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Sally-Ann Poulsen in simple terms?

Sally-Ann Poulsen is an Australian chemical biologist who is a Professor and Director at Griffith University. Her research considers medicinal chemistry and drug discovery.

Why does Sally-Ann Poulsen matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Sally-Ann Poulsen?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Sally-Ann Poulsen.