Scarlet GN, or C.I. Food Red 2, FD&C Red No. 4, or C.I. 14815 is a red azo dye once used as a food dye. As a food additive, it has the E number E125. It is usually used as a disodium salt.
Preparation To synthesize Food Red 2, 2,4-dimethylaniline-6-sulfonic acid is diazotized with sodium nitrite and hydrochloric acid Diazotization. The resulting diazonium salt is reacted with 5-hydroxynaphthalene-1-sulfonic acid via azo coupling.
Use Originally, Food Red 2 was used as a food colorant. Under the designation E 125, Food Red 2 was approved as a food colorant in the EU by Directive 62/2645/EEC until the end of 1976. Food Red 2 is mainly used as a colorant in cosmetics (shampoos, bubble bath, liquid soaps). It is approved in the EU by Regulation (EC) No. 1223/2009. The colorant is also approved for cosmetics in South Africa, Turkey, and Thailand, whereas in Japan and the USA it may not be used in food, pharmaceuticals, or cosmetics. In the United States, it is not permitted for use in food or ingested drugs and may only be used in externally applied drugs and cosmetics, due to potential carcinogenic effects from ingesting it. An exception was added in 1965 to allow its use in the coloring of maraschino cherries, which were considered mainly decorative and not a foodstuff. This exception was repealed and the dye banned in the US on September 22, 1976 due to mounting safety concerns. In the European Union, it is not permitted as a food additive.
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