Sean Brendan Carroll (born September 17, 1960) is an American evolutionary developmental biologist, author, educator and executive producer. He is a distinguished university professor at the University of Maryland and professor emeritus of molecular biology and genetics at the University of Wisconsin–Madison. His studies focus on the evolution of cis-regulatory elements in the regulation of gene expression in the context of biological development, using Drosophila as a model system. He is a member of the National Academy of Sciences, of the American Philosophical Society (2007), of the American Academy of Arts and Sciences and the American Association for Advancement of Science. He is a Howard Hughes Medical Institute investigator. Carroll has received the Stephen Jay Gould Prize from the Society for the Study of Evolution, the Benjamin Franklin Medal in Life Science, and the Lewis Thomas Prize at Rockefeller University. He has produced Emmy-winning films The Farthest and The Serengeti Rules, as well as the Oscar-nominated film All That Breathes.
Biography Sean B. Carroll was born in Toledo, Ohio. He is of Irish ancestry. He has stated that as a child he would flip over rocks looking for snakes while attending Maumee Valley Country Day School, and at age eleven or twelve, he started keeping snakes. This activity led him to notice the patterns on the snakes and wonder how those formed. He graduated from St. Francis de Sales High School in 1977. He got his B.A. in biology at Washington University in St. Louis, his Ph.D. in immunology from Tufts University and did post-doctoral work at the University of Colorado Boulder.
Career Carroll has published extensively on evolutionary developmental biology ("evo-devo"), studying the evolution of regulatory modules that specify body parts and patterns. Carroll is an investigator for the Howard Hughes Medical Institute. In 1987, Carroll set up a laboratory at the University of Wisconsin-Madison "focused on understanding how genes get used in different ways to generate the diversity of form that we see". The Laboratory of Cell and Molecular Biology lists Carroll's interests as "Genetic control of body pattern in fruit flies, butterflies, and other animals". Carroll's team has shown, in a series of papers, how the activation of genes during the embryonic stages of the Drosophila fruit fly controls the development of its wings. The team has been searching for the butterfly's counterparts of these genes. In 2010, he was named vice-president for science education of the Howard Hughes Medical Institute. In 2011, the HHMI launched a documentary film initiative to produce science features for television, to which Carroll was appointed as one of the executive producers. In 2012, Carroll founded HHMI Tangled Bank Studios. In 2012, a film produced by this studio called The Day the Mesozoic Died retraced the investigation that led to the discovery of the asteroid collision that triggered the mass extinction at the end of that Era. The film was introduced by Carroll at a National Teacher's Conference. Carroll was an executive producer of The Farthest, a film about the Voyager program, which won the Emmy in 2018 for outstanding science and technology documentary. Carroll was an executive producer of the 2022 Oscar-nominated documentary All That Breathes, which won the best documentary award at the Cannes Film Festival. Carroll is a proponent of the extended evolutionary synthesis. Since 2013, Carroll has been listed on the Advisory Council of the National Center for Science Education. From September 2009 to March 2013, he wrote a column for The New York Times called "Remarkable Creatures", where he discussed findings in animal evolution.
Awards In 2012, he was awarded the Benjamin Franklin Medal in Life Science from the Franklin Institute "for proposing and demonstrating that the diversity and multiplicity of animal life is largely due to the different ways that the same genes are regulated rather than to mutation of the genes themselves." In 2016, he was awarded the Lewis Thomas Prize by Rockefeller University.
Selected works
Books From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design, with Jennifer Grenier and Scott Weatherbee (2004, Wiley-Blackwell; ISBN 978-1-4051-1950-4) Endless Forms Most Beautiful: The New Science of Evo Devo and the Making of the Animal Kingdom (2005, W. W. Norton & Company; ISBN 978-0-393-06016-4) The Making of the Fittest: DNA and the Ultimate Forensic Record of Evolution (2006, W. W. Norton & Company; ISBN 978-0-393-06163-5) Into the Jungle: Great Adventures in the Search for Evolution (2008, Benjamin Cummings; ISBN 978-0-321-55671-4) Remarkable Creatures: Epic Adventures in the Search for the Origin of Species (2009, Houghton Mifflin Harcourt; ISBN 978-0-15-101485-9) Brave Genius: A Scientist, a Philosopher, and Their Daring Adventures from the French Resistance to the Nobel Prize (2013, Crown; ISBN 978-0-307-95233-2) The Serengeti Rules: The Quest to Discover How Life Works and Why It Matters (2016, Princeton University Press, ISBN 978-0-691-16742-8) A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You (2020), Princeton University Press, ISBN 978-0-691-20175-7.
Magazine articles The Origins of Form: Ancient genes, recycled and re-purposed, control embryonic development in organisms of striking diversity (2005, Natural History Magazine) God as Genetic Engineer. A review of Michael Behe's book "The Edge of Evolution: The Search for the Limits of Darwinism" (2007, Science Magazine) Regulating Evolution: How Gene Switches Make Life (2008, Scientific American)
Filmography
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