sec-Butyl acetate, or s-butyl acetate, is an ester commonly used as a solvent in lacquers and enamels, where it is used in the production of acyclic polymers, vinyl resins, and nitrocellulose. It is a clear flammable liquid with a sweet smell (solvent, fruity, banana). sec-Butyl acetate has three isomers that are also acetate esters: n-butyl acetate, isobutyl acetate, and tert-butyl acetate.
History The first method of production of sec-butyl acetate was the esterification of sec-butanol and acetic anhydride It was experimentally determined and published in 1946 by Rolf Altschul.
Toxicology The LD50 for rats is 13 g/kg. Exposure in humans to significant quantities of sec-butyl acetate can cause irritation to the eyes, mouth, throat, nose, and skin. Ingestion and inhalation of sec-butyl acetate can cause central nervous system depression producing symptoms of dizziness and disorientation.
Nomenclature sec-Butyl acetate is chiral. It has one stereocenter, carbon 2 in the sec-butyl group. The names of the two enantiomers are:
[(2S)-butan-2-yl] acetate, (+)-sec-butyl acetate [(2R)-butan-2-yl] acetate, (−)-sec-butyl acetate
References
External links ChemExpr.com CDC - NIOSH Pocket Guide to Chemical Hazards



