biology

Secretin receptor family

Secretin receptor family is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Secretin receptor family rather than just read about it. In short: Secretin receptor family (class B GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. In early classifications, adhesion G protein-coupled receptors were included as part of the secretin receptor family, but in some more recent classification systems they are considered a distinct family (see for example: GRAFS).

Key takeaways

Secretin receptor family belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Secretin receptor family to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Secretin receptor family from memory before moving on to harder problems.

Reference excerpt

Secretin receptor family (class B GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. In early classifications, adhesion G protein-coupled receptors were included as part of the secretin receptor family, but in some more recent classification systems they are considered a distinct family (see for example: GRAFS). The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have seven transmembrane helices, like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic 7TM signature. The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in fungi, although due to their presumed non-hormonal function they are more commonly referred to as Adhesion G protein-coupled receptors, making the Adhesion subfamily the more basal group. Three distinct sub-families (B1-B3) are recognized.

Subfamily B1 Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.

Pituitary adenylate cyclase-activating polypeptide type 1 receptor InterPro: IPR002285 PACAPR (ADCYAP1R1) Calcitonin receptor InterPro: IPR003287 CALCR Calcitonin receptor-like receptor InterPro: IPR015476 CALCRL Corticotropin-releasing hormone receptor InterPro: IPR003051 CRHR1; CRHR2 Glucose-dependent insulinotropic polypeptide receptor/Gastric inhibitory polypeptide receptor InterPro: IPR001749 GIPR Glucagon receptor InterPro: IPR003291 GCGR Glucagon receptor-related InterPro: IPR003290 GLP1R; GLP2R; Growth hormone releasing hormone receptor InterPro: IPR003288 GHRHR Parathyroid hormone receptor InterPro: IPR002170 PTHR1; PTHR2 Secretin receptor InterPro: IPR002144 SCTR Vasoactive intestinal peptide receptor InterPro: IPR001571 VIPR1; VIPR2

Subfamily B2 Subfamily B2 (also known as the adhesion G protein-coupled receptor family) contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin and brain-specific angiogenesis inhibitor receptors amongst others. However, in some more recent classifications, they are no longer considered part of the same family as secretin (due to significant differences, like autocatalytic processing and different cell functions).

Brain-specific angiogenesis inhibitor InterPro: IPR008077 BAI1; BAI2; BAI3 CD97 antigen InterPro: IPR003056 CD97 EMR hormone receptor InterPro: IPR001740 CELSR1; CELSR2; CELSR3; EMR1; EMR2; EMR3; EMR4 GPR56 orphan receptor InterPro: IPR003910 GPR56; GPR64; GPR97; GPR110; GPR111; GPR112; GPR113; GPR114; GPR115; GPR123; GPR125; GPR126; GPR128; GPR133; GPR144; GPR157 Latrophilin receptor InterPro: IPR003924 ELTD1; LPHN1; LPHN2; LPHN3 Ig-hepta receptor InterPro: IPR008078 GPR116

Subfamily B3 Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.

Diuretic hormone receptor InterPro: IPR002001

Unclassified members HCTR-5; HCTR-6; KPG 006; KPG 008

References

Worked examples

Example 1 — a first encounter with Secretin receptor family

Start with the simplest possible case. Write down what Secretin receptor family claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Secretin receptor family before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Secretin receptor family ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Secretin receptor family

In research: Secretin receptor family appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Secretin receptor family in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Secretin receptor family is common in secondary-school and first-year university syllabi. It links to neighbouring topics G protein-coupled receptors, Protein domains, Protein families, so understanding it makes those chapters shorter.
In everyday life: Look for Secretin receptor family outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Secretin receptor family” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Secretin receptor family in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Secretin receptor family means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Secretin receptor family out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Secretin receptor family in simple terms?

Why does Secretin receptor family matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Secretin receptor family?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Secretin receptor family.