Segmentation is the physical characteristic by which the human body is divided into repeating subunits called segments arranged along a longitudinal axis. In humans, the segmentation characteristic observed in the nervous system is of biological and evolutionary significance. Segmentation is a crucial developmental process involved in the patterning and segregation of groups of cells with different features, generating regional properties for such cell groups and organizing them both within the tissues as well as along the embryonic axis.
Introduction Human nervous system consists of the central nervous system (CNS), which comprises the brain and spinal cord, and the peripheral nervous system (PNS) comprising the nerve fibers that branch off from the spinal cord to all parts of the body. Both parts of the nervous system are actively involved in communicating signals between various parts of the body to ensure the smooth and efficient transfer of information that controls and coordinates the movement of muscles, and regulates organ functions. Neurons, which form the elemental unit of the nervous system, receive messages from their dendrites, relay the information as an electrical signal down the axon and releases chemical messengers known as neurotransmitters, thus converting the electrical signal into a chemical signal.
Segmentation Segmentation is a crucial patterning process that is involved in the development of both the central nervous system and peripheral nervous system. In the central nervous system, segmentation is involved in the patterning of the neuronal population. Added to that, segmentation guides the developing axons and contribute to the development of the peripheral nervous system. In bilateral animals, the fundamental body plan involves the left and right sides as mirror images to each other with a hollow tube of gut cavity from mouth to anus along with a nerve cord with a structure named ganglion for each segment of the body. In fact, most evolutionary evidences point to the postulate that segmentation is an independent evolutionary event that arose multiple times and that the cellular and molecular pathways of segmentation might show differences in different contexts due to this fact.
Biological significance of segmentation The nervous system segmentation confers several developmental advantages to the vertebrate body as humans possess a body plan that is bilaterally segmented at the nervous system level. The segmentation is involved at all levels of the human nervous system with increasing level of complexity in the innervation from the brain to limbs. The presence of conserved features in various species of animals serves as a strong point to the nervous system’s origin from a common ancestor. Also, the neural segments form the basic building block of the human nervous system and these sub units possess their own level of autonomy in both the singular and collective sense. The segments that compose the nervous system, although initially similar in their composition, are later modified by gene expression patterns that are specific to them. Segmental pattern in human beings can be observed clearly during early developmental phase.
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