Self-domestication is a scientific hypothesis that posits the occurrence of a process of artificial selection among human beings, akin to that observed in domesticated animals. This process has been executed by human beings themselves. During the process of hominization, a preference for individuals exhibiting collaborative and social behaviors would have emerged, thereby optimizing the benefits for the entire group. This process of artificial selection would have enhanced docility, language, and emotional intelligence. The hypothesis posits that this distinction is the primary factor that distinguishes Homo sapiens from Homo neanderthalensis and Homo erectus.
Origin and status of the hypothesis In general, domesticated animals possess common characteristics that differentiate them from their non-domesticated counterparts (for example, in the case of Canis familiaris (dogs) compared to their relatives, Canis lupus (wolves), among many other cases): they tend to be more docile and playful, exhibit less aggressive behavior, and show marked neoteny, often resulting in a smaller body, a slightly smaller brain and skull, and shorter teeth and snout. One of the first to scientifically observe that humans present similar traits was the naturalist, anthropologist, and physician Johann Friedrich Blumenbach around 1800. The author of the thesis De generis humani varietate nativa ('On the natural variations in the human lineage') consequently proposed the hypothesis that humans could have been domesticated. A few years later, Charles Darwin addressed the topic using the theory of evolution, which already considered the process of artificial selection in animals. Unable to explain the concept of human domestication from an exclusively scientific perspective (the question of who domesticated humans could only be answered in religious or theistic terms), he eventually dismissed the hypothesis. However, the studies of Dimitri Beliayev in the 20th century were important for the proposal: research on the silver fox demonstrated that in the process of animal domestication, simultaneous changes occurred in behavior (lower levels of adrenaline were observed) and in coat color (alterations in pigmentation): adrenaline could share a biochemical pathway with melanin, a pathway that would be altered during the process of artificial selection. In 2014, scientists Adam Wilkins (from Humboldt University, Berlin), Richard Wrangham (from Harvard University, Massachusetts), and Tecumseh Fitch (from the University of Vienna) proposed that the common origin of these changes lay in neural crest cells, exclusive stem cells of vertebrates that migrate to different parts of the body during the embryonic phase, giving rise to the adrenal glands (responsible for managing the fear and stress response through adrenaline production), melanocytes (responsible for producing skin or coat melanin), and jaws simultaneously. The deficit of these cells would explain the common characteristics of all domesticated animals: tameness, cranial and mandibular reduction, and alterations in pigmentation. Of the three members of the research team, it was primatologist Richard Wrangham who translated these results to humans, asserting that humans have "domesticated" themselves through a process of self-selection (a proposal he would elaborate in "The Goodness Paradox: The Strange Relationship Between Virtue and Violence in Human Evolution").
In July 2019, a team from the Institute of Marine Sciences of Barcelona described, through the methylation of certain genes in DNA, the epigenetic and genetic changes through which neural crest cells were reduced. Subsequently, another research team from the University of Barcelona discovered that the BAZ1B gene controls the behavior of neural crest cells. Comparable with the Neanderthal genome, BAZ1B is also related to genes that have many mutations not present in the homologous genes of our past hominini. Cedric Boeckx, one of the researchers in this study, states:"We believe this means that the genetic network of BAZ1B is an important reason why our face is different compared to other already extinct ancestors, like the Neanderthals [...]. In broad terms, it gives us, for the first time, experimental validation of the autodomestication hypothesis based on the neural crest."
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![Self-domestication: Experiment conducted by the University of Barcelona to demonstrate the hypothesis of self-domestication.[1]](https://upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_self-domestication_and_DNA.jpg/1280px-Human_self-domestication_and_DNA.jpg?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)
