In molecular biology, Six3OS1 is a long non-coding RNA. It was originally identified in the murine embryonic and postnatal retina. It is located in the distal promoter region of the gene encoding Six3, a homeodomain transcription factor. It regulates the activity of Six3 in the developing mouse retina, by binding to transcriptional co-regulators of Six3 and to histone modification enzymes and acting as a transcriptional scaffold.
References
Further reading Geng X, Lavado A, Lagutin OV, Liu W, Oliver G (2007). "Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development". Gene Expr Patterns. 7 (3): 252–257. doi:10.1016/j.modgep.2006.09.007. PMC 1986792. PMID 17084678.
