A sleep disorder, or somnipathy, is a medical disorder that disrupts an individual's sleep patterns and quality. This can cause serious health issues and affect physical, mental, and emotional well-being. Polysomnography and actigraphy are tests commonly ordered for diagnosing sleep disorders. Sleep disorders are classified by the International Classification of Sleep Disorders into insomnia disorders, sleep-related breathing disorders (such as obstructive sleep apnea), central disorders of hypersomnolence (such as narcolepsy), circadian rhythm sleep disorders, parasomnias, and sleep-related movement disorders. When a person struggles to fall or stay asleep without an obvious cause, it is referred to as insomnia, which is the most common sleep disorder. Other sleep disorders include sleep apnea, narcolepsy, idiopathic hypersomnia (excessive sleepiness at inappropriate times), restless legs syndrome, jet lag disorder, rapid eye movement sleep behavior disorder, sleepwalking, and night terrors (also known as sleep terrors). Sleep disruptions can be caused by various issues, including teeth grinding (bruxism). Managing sleep disturbances that are secondary to mental, medical, or substance abuse disorders should focus on addressing the underlying condition. Sleep disorders are common in both children and adults. However, there is a significant lack of awareness about sleep disorders in children, with many cases remaining unidentified. Several common factors involved in the onset of a sleep disorder include increased medication use, age-related changes in circadian rhythms, environmental changes, lifestyle changes, existing physiological problems, and stress. Among the elderly, the risk of developing certain sleep conditions is especially high. These include sleep-disordered breathing, periodic limb movements, restless legs syndrome, REM sleep behavior disorder, insomnia, and circadian rhythm disturbances.
Causes
A systematic review found that traumatic childhood experiences, such as family conflict or sexual trauma, significantly increase the risk of several sleep disorders in adulthood, including sleep apnea, narcolepsy, and insomnia. An evidence-based synopsis suggests that idiopathic REM sleep behavior disorder may have a hereditary component. A total of 632 participants, half with idiopathic REM sleep behavior disorder and half without, completed self-report questionnaires. The study results suggest that people with the sleep disorder are more likely to report having a first-degree relative with the same sleep disorder than people of the same age and sex who do not have the disorder. More research is needed to further understand the hereditary basis of sleep disorders. A population susceptible to the development of sleep disorders includes people who have experienced a traumatic brain injury. Due to the significant research focus on this issue, a systematic review was conducted to synthesize the findings. The results indicate that individuals who have experienced a traumatic brain injury are disproportionately at risk of developing narcolepsy, obstructive sleep apnea, excessive daytime sleepiness, and insomnia. Obstructive sleep apnea is a common condition affecting 10-20% of middle-aged and older adults, characterized by repeated breathing pauses during sleep, leading to poor sleep quality, and excessive daytime somnolence and, sometimes insomnia. Common factors include obesity, narrow airways, and certain neuromuscular conditions that cause airway collapse during sleep.
Sleep disorders and neurodegenerative diseases Neurodegenerative diseases are often associated with sleep disorders, particularly when characterized by the abnormal accumulation of alpha-synuclein, as seen in multiple system atrophy (MSA), Parkinson's disease (PD), Huntington's disease, and Lewy body disease (LBD). For example, individuals diagnosed with PD frequently experience various sleep issues, such as insomnia (affecting approximately 70% of the PD population), hypersomnia (over 50%), and REM sleep behavior disorder (RBD) (around 40%), which is linked to increased motor symptoms. Moreover, RBD has been identified as a significant precursor to the future development of these neurodegenerative diseases over several years, presenting a promising opportunity for improving treatments. Neurodegenerative conditions are commonly related to structural brain impairments, which may disrupt sleep and wakefulness, circadian rhythm, and motor or non-motor functioning. Conversely, sleep disturbances are often linked to worsening of patients' cognitive functioning, emotional state, and quality of life. Additionally, these abnormal behavioral symptoms can place a significant burden on patients' relatives and caregivers. The limited research in this area, coupled with increasing life expectancy, highlights the need for a deeper understanding of the relationship between sleep disorders and neurodegenerative diseases.
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