science

Sofinicline

Sofinicline is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Sofinicline rather than just read about it. In short: Sofinicline (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code names ABT-894 and A-422894.0) is a nicotinic acetylcholine receptor (nAChR) agonist which was under development for the treatment of attention deficit hyperactivity disorder (ADHD), cognition disorders, and diabetic neuropathies but was never marketed. It is taken orally.

Key takeaways

Sofinicline belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Sofinicline to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Sofinicline from memory before moving on to harder problems.

Reference excerpt

Sofinicline (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code names ABT-894 and A-422894.0) is a nicotinic acetylcholine receptor (nAChR) agonist which was under development for the treatment of attention deficit hyperactivity disorder (ADHD), cognition disorders, and diabetic neuropathies but was never marketed. It is taken orally. The drug acts as a highly selective full agonist of the α4β2 nicotinic acetylcholine receptor. It has been found to enhance cognition and memory in rodents. Sofinicline's affinity for the receptor is approximately 0.1 nM. The time to peak levels of sofinicline is 2 to 4 hours and its elimination half-life is 4 to 6 hours. Other pharmacokinetic data for sofinicline have also been reported. Side effects of sofinicline in humans include increased heart rate, nausea, dizziness, headache, and fatigue. Sofinicline was under development by Abbott Laboratories and NeuroSearch. It reached phase 2 clinical trials for ADHD and neuropathic pain and the preclinical research stage of development for cognition disorders prior to the discontinuation of its development.

See also List of investigational attention deficit hyperactivity disorder drugs List of investigational analgesics

References

Illustrations

Worked examples

Example 1 — a first encounter with Sofinicline

Start with the simplest possible case. Write down what Sofinicline claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Sofinicline before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Sofinicline ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Sofinicline

In research: Sofinicline appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Sofinicline in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Sofinicline is common in secondary-school and first-year university syllabi. It links to neighbouring topics Abandoned drugs, Chloroarenes, Drugs not assigned an ATC code, so understanding it makes those chapters shorter.
In everyday life: Look for Sofinicline outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Sofinicline in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Sofinicline means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Sofinicline out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Sofinicline in simple terms?

Why does Sofinicline matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Sofinicline?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Sofinicline.