Sphinganine is a chemical compound of the sphingolipid class with molecular formula C18H39NO2. Via the action of sphingosine kinase enzymes, it is converted to dihydrosphingosine 1-phosphate (sphinganine 1-phosphate), which has a variety of biological functions. Sphinganine is one of many sphingoid bases (long-chain bases) besides sphingosine, which are backbones of sphingolipids. It is made by dehydrogenating 3-ketosphinganine, which is produced by condensation reaction of serine with palmitate. It is an intermediate in the biosynthesis of ceramide. Sphinganine is a diastereomer of safingol.
See also Sphingomonadaceae Serine C-palmitoyltransferase
References
Further reading Qu, Linkai; Wang, Lei; Ji, Hao; Fang, Yimeng; Lei, Pengyu; Zhang, Xingxing; Jin, Libo; Sun, Da; Dong, Hao (2022-03-01). "Toxic Mechanism and Biological Detoxification of Fumonisins". Toxins. 14 (3): 182. doi:10.3390/toxins14030182. ISSN 2072-6651. PMC 8954241. PMID 35324679.