Stearidonic acid (SDA: C18H28O2; 18:4, n-3) is an ω-3 fatty acid, sometimes called moroctic acid.
Biosynthesis It is biosynthesized from alpha-linolenic acid (ALA: C18H30O2; 18:3, n-3) by the enzyme delta-6-desaturase, which removes two hydrogen (H) atoms.
Metabolism Stearidonic acid is involved in the synthesis of longer-chain ω-3 fatty acids in animals (including humans), plants, and bacteria. It is a precursor to eicosapentaenoic acid via a eicosatetraenoic acid (20:4 ω-3) intermediate. Studies in human volunteers and cell cultures suggest that SDA increases EPA levels more efficiently than an equimolar amount of ALA. SDA is also a precursor to N-acylethanolamine (NAEs).
Sources Natural sources of this fatty acid are the seed oils of hemp (between 0.16 and 1.54% of the oil), blackcurrant (between 2.5 and 4.5%), Buglossoides arvensis (corn gromwell), and Echium plantagineum, and the cyanobacterium Spirulina. As it is a precursor to other fatty acids, there has been efforts to enhance the content of stearidonic acid in various crops, such as soybeans. A GMO soybean source is approved by the European Food Safety Authority. SDA can also be synthesized in a lab.
See also List of omega-3 fatty acids Omega-3 fatty acids Essential fatty acids
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