A substituted 3-benzazepine, or simply 3-benzazepine, is a derivative of 3-benzazepine. They are cyclized phenethylamines and are closely related to the tetrahydroisoquinolines. In addition, they are analogous to the cyclized tryptamine ibogalogs and their β-carboline relatives. 3-Benzazepines are known to act as monoamine receptor modulators, including as dopamine D1-like receptor agonists, dopamine D1 receptor antagonists, and serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists, among other activities. 3-Benzazepines acting as serotonin 5-HT2 receptor agonists generally show varying degrees of preferential activity at the serotonin 5-HT2C receptor over the serotonin 5-HT2A receptor, with occasional exceptions. One 3-benzazepine, the non-selective serotonin 5-HT2 receptor agonist and previously marketed anorectic lorcaserin (Belviq), is known to produce psychedelic effects at supratherapeutic doses.
List of 3-benzazepines
Related compounds
See also Benzazepine Cyclized phenethylamine Substituted tetrahydroisoquinoline Ibogalog Iboga alkaloid Substituted β-carboline
References

![Substituted 3-benzazepine: SKF-81297, a dopamine D1-like receptor agonist of the 3-benzazepine group.[1]](https://upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Skf-81297.svg/500px-Skf-81297.svg.png?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)




