ArticleslgStudy

chemistry

Suritozole

Suritozole is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Suritozole rather than just read about it. In short: Suritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABAA ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM.

Suritozole — main illustration
Suritozole — illustration

Key takeaways

  • Suritozole belongs to chemistry; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect Suritozole to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of Suritozole from memory before moving on to harder problems.

Reference excerpt

Suritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABAA ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM. It was investigated for the treatment of depression and Alzheimer's disease in the 90s, but clinical development seems to have been discontinued.

Synthesis

The reaction between monomethylhydrazine [60-34-4] (1) and methyl isothiocyanate (Trapex) [556-61-6] (2) gave 2,4-dimethylthiosemicarbazide [6621-75-6] (3). Amide formation with 3-fluorobenzoyl chloride [1711-07-5] (4) yielded 1-(3-fluorobenzoyl)-2,4-dimethylthiosemicarbazide [110623-52-4] (5). Cyclization to Suritozole (6).

See also GABAA receptor negative allosteric modulator GABAA receptor § Ligands

References

Illustrations

Suritozole illustration
Suritozole: Synthesis:[3][4] ~85%:[5] Patents:[6][7] etc
Synthesis:[3][4] ~85%:[5] Patents:[6][7] etc

Worked examples

Example 1 — a first encounter with Suritozole

Start with the simplest possible case. Write down what Suritozole claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Suritozole before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Suritozole ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Suritozole

In research
Suritozole appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses Suritozole in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
Suritozole is common in secondary-school and first-year university syllabi. It links to neighbouring topics 3-Fluorophenyl compounds, Drugs not assigned an ATC code, GABAA receptor negative allosteric modulators, so understanding it makes those chapters shorter.
In everyday life
Look for Suritozole outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Suritozole in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what Suritozole means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain Suritozole out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Suritozole in simple terms?

Suritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABAA ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM.

Why does Suritozole matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Suritozole?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Suritozole.

Tags

  • 3-Fluorophenyl compounds
  • Drugs not assigned an ATC code
  • GABAA receptor negative allosteric modulators
  • Nervous system drug stubs
  • Nootropics
  • Thiocarbonyl compounds
  • Triazoles

Keep exploring