Synovial sarcoma, X breakpoint (SSX) refers to a group of genes rearranged in synovial sarcoma. They include:
SSX1 SSX2 and SSX2B SSX3 SSX4 and SSX4B SSX5 SSX6 SSX7 SSX8 SSX9 SSX10 The group also has several associated pseudogenes, and the interacting protein SSX2IP. The translocation t(X;18) creates a fusion of the SYT gene(at 18q11) with either SSX1 or SSX2 (both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding domains. Instead, they appear to be transcriptional regulators whose actions are mediated primarily through protein–protein interactions, with BRM in the case of SYT, and with Polycomb group repressors in the case of SSX.
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