T2-induced deoxynucleotide kinase (EC 2.7.4.12) is an enzyme that catalyzes two related chemical reactions. The first converts the nucleotide, deoxyguanosine monophosphate, to deoxyguanosine diphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).
Similarly, thymidine monophosphate is converted to thymidine diphosphate:
The enzyme was characterised from Escherichia coli infected with the virus, enterobacteria phage T2, and carried out these reactions at rates up to 20 times those of uninfected cells. This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(d)NMP phosphotransferase.
References





