In enzymology, a tRNA-queuosine beta-mannosyltransferase (EC 2.4.1.110) is an enzyme that catalyzes the chemical reaction
GDP-mannose + tRNAAsp-queuosine ⇌ {\displaystyle \rightleftharpoons } GDP + tRNAAsp-O-5"-beta-D-mannosylqueuosine Thus, the two substrates of this enzyme are GDP-mannose and tRNAAsp-queuosine, whereas its two products are GDP and tRNAAsp-O-5''-beta-D-mannosylqueuosine. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:tRNAAsp-queuosine O-5"-beta-D-mannosyltransferase.
References
Okada N, Nishimura S (1977). "Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver". Nucleic Acids Res. 4 (8): 2931–8. doi:10.1093/nar/4.8.2931. PMC 342620. PMID 20603.
