Modes of mechanical ventilation refers to the methods a Ventilator offers to assist or replace spontaneous breathing. Modern Ventilators provide a number of such Modes (derived from Modus operandi) to enable the most suitable respiratory support for the individual patient. Each Mode has its particular set of Controls to adapt the breath delivery to the patient. CAVEAT: Although manufacturers may offer identical breath delivery methods, the names of the Modes may be different.
Overview Commercially available ventilators offer different Modes of breath delivery, each with its particular set of control knobs. Breath delivery methods and terminology are not standardized and can thus be quite confusing. However, by and large, they can be grouped into Basic Modes, Dual Control Modes and Adaptive Modes. Three tables are provided below to illustrate these three groups. NOTE: not all controls on a ventilator are part of a Mode, for example alarm settings and monitoring values are used independent of the Mode. Also, the control to set the percentage oxygen (fraction of inspired oxygen, FiO2) is not part of a Mode.
Basic Modes In the basic breath delivery Modes, the ventilator acts as a high-fidelity delivery device. The clinician's settings are direct commands to the inspiratory and expiratory valve controls. The ventilator uses fast sensors for intra-breath control to match the clinicians settings exactly. Breath delivery follows the phases of breathing, i.e., inhalation and exhalation. Each Mode defines how breath delivery and timing can be controlled by the clinician.
Definition of terms
Start of inhalation (Trigger) The start of inhalation is initiated either by the machine or the patient and that point in time is called Inspiratory Trigger. The ventilator needs to know when to start delivering gas to the patient. If the patient does not breathe at all, a timer starts inhalation. If the patient has some breathing activity, the ventilator can sense this effort by measuring pressure or flow and start inhalation if pressure or flow drop below a certain threshold. That threshold is called Trigger Sensitivity. Thus, the controls available to the clinician are respiratory rate and trigger sensitivity. NOTE: Trigger sensitivity plays a double role. Evidently, it determines the start of inhalation and, by the same toke, it ends expiration. For example, if trigger sensitiviy is set too sensive, it may influence respiratory rate and create tachypnea.
Inhalation and breath delivery Once the ventilators is triggered to deliver respiratory gas, two methods to deliver the gas mixture are technically possible: flow controlled or pressure controlled gas gelivery. Both methods have their advantages and disadvantages. If flow controlled gas delivery is chosen, it is often combined with a Volume limit which stops gas delivery when a set volume is reached. Thus, the term Volume Controlled Ventilation is often used. The controls available to the clinician are inspiratory pressure, inspiratory flow and/or inspiratory volume.
Start of exhalation (Cycling) Inhalation must eventually stop and cycle to exhalation to enable the lungs to exhale. If the patient does not breathe, the ventilator must switch to exhalation after a pre-set time (time cycled) has elapsed, a certain pressure is exceeded (pressure cycled) or a pre-set volume (volume cycled) has been delivered. If the patient has some breathing activity, the ventilator can sense this by measuring flow and start exhalation, for example, if flow drops below a certain threshold. That threshold may be termed "Expiratory Trigger Sensitivity". The controls available to the clinician are inspiratory time, inspiratory volume, inspiratory flow, maximum pressure and/or expiratory trigger sensitivity. NOTE: Inspiratory flow can be expressed as V'I = Vt/Ti and respiratory rate f = 60/(Ti+Te). Both formulas have three variables and two degrees of freedom. This means that only two variables can be controlled independently, the third variable follows.
Exhalation Emtpying the lungs requires time which starts with the onset of exhalation and ends with the start of the subsequent inhalation. If the patient is passive, the exhalation is terminated by a timer. If the patient has some breathing activity, exhalation may be terminated by the subsequent inhalation effort of the patient. Controls include a selection of expiratory time, respiratory rate and/or trigger sensitivity. NOTE: The pressure maintained throughout exhalation is termed Positive End-Expiratory Pressure PEEP. CPAP differs from PEEP because the patient can inhale and exhale in CPAP.
Table of Basic Modes and their acronyms The table below lists the working principles of some of the common Modes of ventilation.
Breath delivery mechanism: Flow means that the ventilator controls the valve to maintain a set flow independent of pressure or volume. Pressure means that the ventilator maintains a set pressure, independent of flow and volume. Trigger: start of inhalation Cycling: start of exhalation Vent means controlled by ventilator based on settings by clinician. Pat means controlled by patient, based on measurements of flow, pressure or muscle activity.
PAV and NAVA were designed to provide superior synchrony with the patient's breathing by using a physiological signal as the command source.
Dual Control Modes Dual Control Modes introduce an outer control loop that wraps around a Basic Mode. The clinician sets a performance target (for example Vt and respiratory rate) and the ventilator then uses a Basic Mode (usually a pressure-controlled or pressure-support breath) as its actuator and automatically adjusts the pressure level from breath to breath to meet the performance target. This represents a significant user-interface advantage. The clinician can manage the fundamental goals of ventilation—for example tidal volume or respiratory rate —while the machine handles the technical translation into the required pressure, adapting automatically to changes in the patient's respiratory system compliance and resistance and spontaneous activity.
Table of Dual Control Modes and their acronyms The table below lists the working principles of some of the Dual Control Modes. The clinician set a desired target, for example the tidal volume Vt and the ventilator adjusts one of the variables of provided by the basic mode it uses.
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