engineering

Taxane 13alpha-hydroxylase

Taxane 13alpha-hydroxylase is a engineering topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Taxane 13alpha-hydroxylase rather than just read about it. In short: In enzymology, a taxane 13alpha-hydroxylase (EC 1.14.13.77) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-ol + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } taxa-4(20),11-dien-5alpha,13alpha-diol + NADP+ + H2O The 4 substrates of this enzyme are taxa-4(20),11-dien-5alpha-ol, NADPH, H+, and O2, whereas its 3 products are taxa-4(20),11-dien-5alpha,13alpha-diol, NADP+, and H2O. Thi…

Key takeaways

Taxane 13alpha-hydroxylase belongs to engineering; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Taxane 13alpha-hydroxylase to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Taxane 13alpha-hydroxylase from memory before moving on to harder problems.

Reference excerpt

In enzymology, a taxane 13alpha-hydroxylase (EC 1.14.13.77) is an enzyme that catalyzes the chemical reaction

taxa-4(20),11-dien-5alpha-ol + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } taxa-4(20),11-dien-5alpha,13alpha-diol + NADP+ + H2O The 4 substrates of this enzyme are taxa-4(20),11-dien-5alpha-ol, NADPH, H+, and O2, whereas its 3 products are taxa-4(20),11-dien-5alpha,13alpha-diol, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating). This enzyme participates in diterpenoid biosynthesis.

References

Wheeler AL, Long RM, Ketchum RE, Rithner CD, Williams RM, Croteau R (2001). "Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells". Arch. Biochem. Biophys. 390 (2): 265–78. doi:10.1006/abbi.2001.2377. PMID 11396929. Jennewein S, Rithner CD, Williams RM, Croteau RB (2001). "Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13595–600. Bibcode:2001PNAS...9813595J. doi:10.1073/pnas.251539398. PMC 61086. PMID 11707604.

Worked examples

Example 1 — a first encounter with Taxane 13alpha-hydroxylase

Start with the simplest possible case. Write down what Taxane 13alpha-hydroxylase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In engineering, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Taxane 13alpha-hydroxylase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Taxane 13alpha-hydroxylase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Taxane 13alpha-hydroxylase

In research: Taxane 13alpha-hydroxylase appears in engineering research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Taxane 13alpha-hydroxylase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Taxane 13alpha-hydroxylase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 1.14.13, EC 1.14.13 stubs, Enzymes of unknown structure, so understanding it makes those chapters shorter.
In everyday life: Look for Taxane 13alpha-hydroxylase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Taxane 13alpha-hydroxylase in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Taxane 13alpha-hydroxylase means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Taxane 13alpha-hydroxylase out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Taxane 13alpha-hydroxylase in simple terms?

In enzymology, a taxane 13alpha-hydroxylase (EC 1.14.13.77) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-ol + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } taxa-4(20),11-dien-5alpha,13alpha-diol + NADP+ + H2O The 4 substrates of this enzyme are taxa-4(20),11-d…

Why does Taxane 13alpha-hydroxylase matter?

Because it connects several engineering ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Taxane 13alpha-hydroxylase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Taxane 13alpha-hydroxylase.