Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene. The testicular receptor 4 is a member of the nuclear receptor family of transcription factors. Though currently considered an orphan receptor, it nevertheless has an important role as a core DNA binding component of the so called DRED complex (direct repeat erythroid determinant). This complex is formed out of TR4, testicular receptor 2, DNMT1, and KDM1A, and functions as a gene repressor the regulates the expression of red blood cell globin. In particular, it contributes to the transition from fetal to adult pattern expression.
Interactions Testicular receptor 4 has been shown to interact with
Androgen receptor, Estrogen receptor alpha, and Hepatocyte nuclear factor 4 alpha.
See also Testicular receptor
References
Further reading
External links FactorBook TR4






