Tetrahydroharman, or tetrahydroharmane, also known as 1-methyl-1,2,3,4-tetrahydro-β-carboline, is a β-carboline and general name for one of two isomers:
(1S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Calligonine ((1R)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole) Calligonine is a major alkaloid constituent of the roots of Calligonum minimum and the bark of Elaeagnus angustifolia. When taken internally, it has the effect of substantially lowering blood pressure for an extended period of time, similar to reserpine.
See also Substituted β-carboline Peganum harmala Harmala alkaloid
References Landolt-Börnstein Badger, Geoffrey M.; A. F. Beecham (1951). "Isolation of Tetrahydroharman from Petalostyles labicheoides". Nature. 168 (4273): 517–518. Bibcode:1951Natur.168..517B. doi:10.1038/168517b0. PMID 14875146. S2CID 4155160. Harborne, Jeffrey B.; Herbert Baxter; Gerard Moss (1999). Phytochemical Dictionary: A Handbook of Bioactive Compounds from Plants (2 ed.). CRC Press. p. 195. ISBN 0-7484-0620-4. Kar, Ashutosh (2003). Pharmacognosy and Pharmacobiotechnology. New Age Publishers. p. 580. ISBN 81-224-1501-6.


