In enzymology, tetrahydroxynaphthalene reductase (EC 1.1.1.252) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are scytalone and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are naphthalene-1,3,6,8-tetrol, reduced NADPH, and a proton. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.
Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1DOH, PDB: 1G0N, and PDB: 1G0O.
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