Thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
The enzyme characterised from maize converts thiamine pyrophosphate to thiamine triphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).
Nomenclature The enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:thiamine-diphosphate phosphotransferase. Other names in common use include ATP:thiamin-diphosphate phosphotransferase, TDP kinase, thiamin diphosphate kinase, thiamin diphosphate phosphotransferase, thiamin pyrophosphate kinase, thiamine diphosphate kinase, and protein bound thiamin diphosphate:ATP phosphoryltransferase.
See also Thiamine-triphosphatase
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