Thiopropazate (Artalan, Dartal, Dartalan, Dartan) is a typical antipsychotic of the phenothiazine class. It is a prodrug to perphenazine. Thiopropazate is manufactured by Searle (US, UK) & Boehringer Mannheim (Germany) Thiopropazate is sold by Chembase, AAA Chemistry, ZINC, AKos Consulting & Solutions, Boc Sciences, ChemFrog, and ChemMol
Synthesis
The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine [2765-59-5] (1) with Piperazine (2) gives N-Desmethylprochlorperazine [40323-85-1] (3). Further alkylation with 2-Bromoethyl acetate [927-68-4] (4) gives Thiopropazate (5).
See also Typical antipsychotic Phenothiazine
References


![Thiopropazate: Thieme Patent:[4]](https://upload.wikimedia.org/wikipedia/commons/thumb/6/62/Thiopropazate_synthesis.svg/500px-Thiopropazate_synthesis.svg.png?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)
