Thiotimoline is a fictitious chemical compound conceived by American biochemist and science fiction author Isaac Asimov. It was first described in a spoof scientific paper titled "The Endochronic Properties of Resublimated Thiotimoline" in 1948. The major peculiarity of the chemical is its "endochronicity": it starts dissolving before it makes contact with water. Asimov went on to write three additional short stories, each describing different properties or uses of thiotimoline.
Chemical properties In Asimov's writings the endochronicity of thiotimoline is explained by the fact that in the thiotimoline molecule, there is at least one carbon atom such that, while two of the carbon's four chemical bonds lie in normal space and time, one of the bonds projects into the future and another into the past. Thiotimoline is derived from the bark of the (fictitious) shrub Rosacea karlsbadensis rufo, and the thiotimoline molecule includes at least fourteen hydroxy groups, two amino groups, and one sulfonic acid group, and possibly one nitro compound group as well. The nature of the hydrocarbon nucleus is unknown, although it seems in part to be an aromatic hydrocarbon.
Background In 1947 Asimov was engaged in doctoral research in chemistry and, as part of his experimental procedure, he needed to dissolve catechol in water. As he observed the crystals dissolve as soon as they hit the water's surface, it occurred to him that if catechol were any more soluble, then it would dissolve before it encountered the water. By that time Asimov had been writing professionally for nine years and would soon write a doctoral dissertation. He feared that the experience of writing readable prose for publication (i.e. science fiction) might have impaired his ability to write the turgid prose typical of academic discourse, and decided to practice with a spoof article (including charts, graphs, tables, and citations of fake articles in nonexistent journals) describing experiments on a compound, thiotimoline, that was so soluble that it dissolved in water up to 1.12 seconds before the water was added. Asimov wrote the article on 8 June 1947, but was uncertain as to whether the resulting work of fiction was publishable. John W. Campbell, the editor of Astounding Science Fiction, accepted it for publication on 10 June, agreeing to Asimov's request that it appear under a pseudonym in deference to Asimov's concern that he might alienate potential doctoral examiners at Columbia University if he were revealed as the author. Some months later Asimov was alarmed to see the piece appear in the March 1948 issue of Astounding under his own name, and copies of the issue circulated at the Columbia chemistry department. Asimov believed that Campbell had done so out of greater wisdom. His examiners told him that they accepted his dissertation by asking a final question about thiotimoline, resulting in him having to be led from the room while laughing hysterically with relief. The article made Asimov famous for the first time outside science fiction, as chemists shared copies of the article. He heard that many children went to the New York Public Library trying to find the nonexistent journals.
"The Micropsychiatric Applications of Thiotimoline" In 1952, Asimov wrote a second spoof scientific paper on thiotimoline called "The Micropsychiatric Applications of Thiotimoline". Like the first, it included charts, graphs, tables, and citations of fake articles from fake journals (along with one real citation: Asimov's own earlier spoof article from Astounding, which was listed tongue-in-cheek as the Journal of Astounding Science Fiction). This second article described the use of thiotimoline to establish a quantitative classification of "certain mental disorders". It also expounds a putative rationale for thiotimoline's behaviour: namely that the chemical bonds in the compound's structural formula are so starved of space that some are forced into the time dimension. According to the second article, thiotimoline's time of solubility varies depending on the determination of the person adding the water. It also claims that one effect is that when people with multiple personalities add the water, some parts of the thiotimoline dissolve before others, due to some of the individual's personalities being more determined than others. "The Micropsychiatric Applications of Thiotimoline" appeared in the December 1953 issue of Astounding. The first two thiotimoline "articles" appeared together in Asimov's first collection of science essays, Only a Trillion (1957), under the joint title "The Marvellous Properties of Thiotimoline". Asimov also included the original article in his 1972 collection The Early Asimov. The first article also appeared in Fifty Years of the Best Science Fiction from Analog (Davis Publications, 1982).
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