chemistry

Tochergamine

Tochergamine is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Tochergamine rather than just read about it. In short: Tochergamine, also known as 621 I.S. or as N,N-diethyl-N′-(1,2,3,4-tetrahydronaphthyl)glycinamide, is an oxytocic drug related to ergometrine which does not appear to have been marketed. It was reported to be effective as an oxytocic agent in animal studies, with oxytocic activity equivalent to that of ergometrine.

Key takeaways

Tochergamine belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Tochergamine to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Tochergamine from memory before moving on to harder problems.

Reference excerpt

Tochergamine, also known as 621 I.S. or as N,N-diethyl-N′-(1,2,3,4-tetrahydronaphthyl)glycinamide, is an oxytocic drug related to ergometrine which does not appear to have been marketed. It was reported to be effective as an oxytocic agent in animal studies, with oxytocic activity equivalent to that of ergometrine. In addition, the drug was reported to be effective in clinical studies at doses of 2 to 6 mg parenterally. However, subsequent research found that it was inactive on the intact human uterus at doses of up to 20 mg, and further investigation of tochergamine was abandoned. Tochergamine has a simplified lysergamide-like chemical structure, with a 1-aminotetralin ring system, and is structurally related to lysergamides like ergometrine and LSD. However, it is not technically a partial ergoline or lysergamide, only partial ergoline-like, as its structural features differ in certain regards from those of ergolines and lysergamides. The oxytocic effects of lysergamides like ergometrine are thought to most likely be mediated by agonism of serotonin 5-HT2 receptors in uterine smooth muscle tissue. Tochergamine was first described in the scientific literature in 1951. It was developed by Daniel Bovet and colleagues at the Istituto Superiore di Sanità in Rome, Italy. The drug was known as tochergamina in Italy. It was clinically studied as an oxytocic agent in the 1950s. Analogues of tochergamine, for instance the 2-aminotetralin positional isomer, have also been described, and have likewise shown oxytocic and lysergic acid-like activity.

Illustrations

Worked examples

Example 1 — a first encounter with Tochergamine

Start with the simplest possible case. Write down what Tochergamine claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Tochergamine before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Tochergamine ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Tochergamine

In research: Tochergamine appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Tochergamine in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Tochergamine is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1-Aminotetralins, Abandoned drugs, Carboxamides, so understanding it makes those chapters shorter.
In everyday life: Look for Tochergamine outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Tochergamine in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Tochergamine means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Tochergamine out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Tochergamine in simple terms?

Why does Tochergamine matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Tochergamine?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Tochergamine.