biology

Transmembrane domain of ABC transporters

Transmembrane domain of ABC transporters is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Transmembrane domain of ABC transporters rather than just read about it. In short: ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of 6 to 10 alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family (Pfam PF00005) have two such regions.

Key takeaways

Transmembrane domain of ABC transporters belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Transmembrane domain of ABC transporters to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Transmembrane domain of ABC transporters from memory before moving on to harder problems.

Reference excerpt

ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of 6 to 10 alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family (Pfam PF00005) have two such regions. This family appears to correspond to ABC1 by TCDB classification.

Subfamilies Sulphate ABC transporter permease protein 2 InterPro: IPR005667 Phosphate transport system permease protein 2 InterPro: IPR005672 Phosphonate uptake transporter InterPro: IPR005769 Nitrate transport permease InterPro: IPR005889 NifC-like ABC-type porter InterPro: IPR006469 Phosphate ABC transporter, permease protein PstC InterPro: IPR011864 Molybdate ABC transporter, permease protein InterPro: IPR011867 Nickel ABC transporter, permease subunit NikB InterPro: IPR014156 Nickel ABC transporter, permease subunit NikC InterPro: IPR014157 Ectoine/hydroxyectoine ABC transporter, permease protein EhuD InterPro: IPR014341 Ectoine/hydroxyectoine ABC transporter, permease protein EhuC InterPro: IPR014342

Human proteins containing this domain ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; TAP1; TAP2; TAPL;

References

Worked examples

Example 1 — a first encounter with Transmembrane domain of ABC transporters

Start with the simplest possible case. Write down what Transmembrane domain of ABC transporters claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Transmembrane domain of ABC transporters before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Transmembrane domain of ABC transporters ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Transmembrane domain of ABC transporters

In research: Transmembrane domain of ABC transporters appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Transmembrane domain of ABC transporters in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Transmembrane domain of ABC transporters is common in secondary-school and first-year university syllabi. It links to neighbouring topics ATP-binding cassette transporters, Membrane protein stubs, Protein domains, so understanding it makes those chapters shorter.
In everyday life: Look for Transmembrane domain of ABC transporters outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Transmembrane domain of ABC transporters in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Transmembrane domain of ABC transporters means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Transmembrane domain of ABC transporters out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Transmembrane domain of ABC transporters in simple terms?

Why does Transmembrane domain of ABC transporters matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Transmembrane domain of ABC transporters?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Transmembrane domain of ABC transporters.