biology

Transmembrane protein 151B

Transmembrane protein 151B is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Transmembrane protein 151B rather than just read about it. In short: Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene. Nomenclature The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.

Key takeaways

Transmembrane protein 151B belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Transmembrane protein 151B to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Transmembrane protein 151B from memory before moving on to harder problems.

Reference excerpt

Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene.

Nomenclature The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.

Gene The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs. It is a complex locus that contains both TMEM151B and SPATS1. TMEM151B has one paralog: TMEM151A.

Transcript The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp.

Protein

The protein has a length of 566 amino acids and contains two transmembrane domains. According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72. The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor.

Expression

RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes. NCBI geo profiles similarly show localization to the brain tissues. Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas.

Protein interactions The TMEM151B protein interacts with one other protein according to BioGRID.

SREBF2- a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane; activates genes involved with cholesterol biosynthesis.

Homology and evolution

The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B. The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.

Research Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer. It was also found to be up-regulated in post-menopausal breast cancer. A SNP found within TMEM151B is associated with the development of lean muscle.

References

Illustrations

Worked examples

Example 1 — a first encounter with Transmembrane protein 151B

Start with the simplest possible case. Write down what Transmembrane protein 151B claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Transmembrane protein 151B before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Transmembrane protein 151B ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Transmembrane protein 151B

In research: Transmembrane protein 151B appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Transmembrane protein 151B in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Transmembrane protein 151B is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 6, Human chromosome 6 gene stubs, so understanding it makes those chapters shorter.
In everyday life: Look for Transmembrane protein 151B outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Transmembrane protein 151B in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Transmembrane protein 151B means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Transmembrane protein 151B out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Transmembrane protein 151B in simple terms?

Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene. Nomenclature The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.

Why does Transmembrane protein 151B matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Transmembrane protein 151B?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Transmembrane protein 151B.