biology

Transmembrane protein 175

Transmembrane protein 175 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Transmembrane protein 175 rather than just read about it. In short: Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

Key takeaways

Transmembrane protein 175 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Transmembrane protein 175 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Transmembrane protein 175 from memory before moving on to harder problems.

Reference excerpt

Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

Expression Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level (75-98%) in normal tissues. TMEM175 appears to be down regulated in stage three ovarian cancer.

Homology Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLAST and BLAT. This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.

Predicted Post-Translational Modification Using various tools at ExPASy the following are possible post-translational modifications for TMEM175.

5 possible CK2 phosphorylation sites 2 possible PKC phosphorylation sites N-myristoylation sites around transmembrane regions The N-myristoylation sites are conserved in vertebrates.

References

Further reading "Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases". National Institutes of Health (NIH). 2021-02-16. Retrieved 2023-08-07.

Illustrations

Worked examples

Example 1 — a first encounter with Transmembrane protein 175

Start with the simplest possible case. Write down what Transmembrane protein 175 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Transmembrane protein 175 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Transmembrane protein 175 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Transmembrane protein 175

In research: Transmembrane protein 175 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Transmembrane protein 175 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Transmembrane protein 175 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 4, Membrane protein stubs, so understanding it makes those chapters shorter.
In everyday life: Look for Transmembrane protein 175 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Transmembrane protein 175 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Transmembrane protein 175 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Transmembrane protein 175 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Transmembrane protein 175 in simple terms?

Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

Why does Transmembrane protein 175 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Transmembrane protein 175?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Transmembrane protein 175.