biology

Transmembrane protein 205

Transmembrane protein 205 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Transmembrane protein 205 rather than just read about it. In short: Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene. Gene TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981.

Key takeaways

Transmembrane protein 205 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Transmembrane protein 205 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Transmembrane protein 205 from memory before moving on to harder problems.

Reference excerpt

Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene.

Gene TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981. In close proximity to TMEM205, CCDC159 is located slightly upstream and RAB3D slightly down stream of the genomic sequence.

Homology TMEM205 has no known Paralogs in the Human genome. Using UCSC genome browser BLAT against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the Bushbaby. TMEM205 does however have a large range of ortholog sequences.

Protein The human homologue of TMEM205 is 189 amino acids long and has a molecular weight of 21.2 kDa. It contains 4 hydrophobic helical domains that are predicted to be transmembrane domains.

Expression TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues. The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.

Function TMEM205 is thought to be a multi-pass transmembrane protein. It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin. It contains four domains predicted to be trans membrane domains by TMHMM analysis.

Interacting proteins TMEM205 has been shown to be co-located with RAB8 a known GTPase involved in vesicular traffic.

Clinical significance TMEM205 has been shown to be involved in Cisplatin resistance. Cisplatin is a chemotherapeutic drug that is commonly used to treat solid malignancies such as carcinomas, sarcomas, and lymphomas. In addition to being involved in Cisplatin resistance there is growing evidence that the protein is also involved in the diseases thyroiditis and prostatitis

Notes

Illustrations

Worked examples

Example 1 — a first encounter with Transmembrane protein 205

Start with the simplest possible case. Write down what Transmembrane protein 205 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Transmembrane protein 205 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Transmembrane protein 205 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Transmembrane protein 205

In research: Transmembrane protein 205 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Transmembrane protein 205 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Transmembrane protein 205 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 19, Proteins, so understanding it makes those chapters shorter.
In everyday life: Look for Transmembrane protein 205 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Transmembrane protein 205 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Transmembrane protein 205 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Transmembrane protein 205 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Transmembrane protein 205 in simple terms?

Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene. Gene TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981.

Why does Transmembrane protein 205 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Transmembrane protein 205?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Transmembrane protein 205.