biology

Transmembrane protein 222

Transmembrane protein 222 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Transmembrane protein 222 rather than just read about it. In short: Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene. One notable feature of the protein encoded by this gene is the presence of three predicted transmembrane domains.

Key takeaways

Transmembrane protein 222 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Transmembrane protein 222 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Transmembrane protein 222 from memory before moving on to harder problems.

Reference excerpt

Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene. One notable feature of the protein encoded by this gene is the presence of three predicted transmembrane domains. The TMEM222 protein is predicted to most likely localize to the secretory vesicles.

Gene Features TMEM222 has a domain of unknown function (DUF778). Aliases of this gene include DKFZP564D0478, RP11-4K3__A.4, C1orf160, and MGC111002. Accession NM_032125.2, the longest coding sequence (1629 bp), encodes a protein of 208 amino acid residues (23230 daltons), which is considered the consensus coding sequence (CCDS297.2). There are two isoforms of the protein encoded by this gene. They are similar except the second (Q9H0R3-2) is lacking the first 96 amino acid residues that are present in the first (Q9H0R3-1).

Gene Expression ACEVIEW has labeled TMEM222 as highly expressed with 3.8 times more expression than the average gene in the database. There is expression evidence from 166 tissues including brain, lung, colon, kidney, and placenta.

Homology Orthologs and distant homologs of the human TMEM222 have been identified throughout Eukaryota especially in plants and animals. No paralogs of this gene have been found in the human genome.

Distant Homolog A distant homolog of TMEM222, RTH (RTE1-Homolog), is a homolog of RTE1 (Reversion-to-Ethylene Perception 1), which is known to induce conformational changes in ETR1 (Ethylene receptor 1) that result in negative regulation corresponding with loss of ethylene perception.

Protein Interactions Evidence from yeast two-hybrid screening exists for two protein interactions with this gene. One is a serine protease (PRSS23) that has been identified to be involved in mouse ovulation and is excreted into the extracellular matrix. The other protein is an ab-hydrolase (HLA-B associated transcript 5) that is integral to the membrane, and its corresponding gene is located in the genome near Tumor Necrosis Factor (TNF)-alpha and TNF-beta.

References

Illustrations

Worked examples

Example 1 — a first encounter with Transmembrane protein 222

Start with the simplest possible case. Write down what Transmembrane protein 222 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Transmembrane protein 222 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Transmembrane protein 222 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Transmembrane protein 222

In research: Transmembrane protein 222 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Transmembrane protein 222 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Transmembrane protein 222 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 1, Uncharacterized proteins, so understanding it makes those chapters shorter.
In everyday life: Look for Transmembrane protein 222 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Transmembrane protein 222 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Transmembrane protein 222 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Transmembrane protein 222 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Transmembrane protein 222 in simple terms?

Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene. One notable feature of the protein encoded by this gene is the presence of three predicted transmembrane domains.

Why does Transmembrane protein 222 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Transmembrane protein 222?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Transmembrane protein 222.