In enzymology, a trimethylsulfonium-tetrahydrofolate N-methyltransferase (EC 2.1.1.19) is an enzyme that catalyzes the chemical reaction
trimethylsulfonium + tetrahydrofolate ⇌ {\displaystyle \rightleftharpoons } dimethylsulfide + 5-methyltetrahydrofolate Thus, the two substrates of this enzyme are trimethylsulfonium and tetrahydrofolate, whereas its two products are dimethyl sulfide and 5-methyltetrahydrofolate. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylsulfonium:tetrahydrofolate N-methyltransferase. This enzyme is also called trimethylsulfonium-tetrahydrofolate methyltransferase. This enzyme participates in one carbon pool by folate.
References
Wagner C, Lusty SM, Kung HF, Rogers NL (1967). "Preparation and properties of trimethylsulfonium-tetrahydrofolate methyltransferase". J. Biol. Chem. 242 (6): 1287–93. doi:10.1016/S0021-9258(18)96177-6. PMID 6023571.
