Triokinase/FMN cyclase is an enzyme that in humans is encoded by the TKFC gene (previously DAK). Triokinase/FMN cyclase represses the cellular antiviral response triggered by the RNA-sensor IFIH1.
Function This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclic FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined.
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