UDP-sulfoquinovose synthase (EC 3.13.1.1) is an enzyme that catalyzes the chemical reaction
UDP-glucose + sulfite ⇌ {\displaystyle \rightleftharpoons } UDP-6-sulfoquinovose + H2O Thus, the two substrates of this enzyme are UDP-glucose and sulfite, whereas its two products are UDP-6-sulfoquinovose and H2O. In a subsequent reaction catalyzed by sulfoquinovosyl diacylglycerol synthase, the sulfoquinovose portion of UDP-sulfoquinovose is combined with diacyglycerol to produce the sulfolipid sulfoquinovosyl diacylglycerol (SQDG). This enzyme belongs to the family of hydrolases, specifically those acting on carbon-sulfur bonds. The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include sulfite:UDP-glucose sulfotransferase, and UDP-sulfoquinovose synthase. This enzyme participates in nucleotide sugars metabolism and glycerolipid metabolism. The 3-dimensional structure of the enzyme is known from Protein Data Bank entries 1qrr (Mulichak et al., 1999), 1i24, 1i2b and 1i2c.
See also Sulfoquinovose
References
Essigmann B, Guler S, Narang RA, Linke D, Benning C (1998). "Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1950–5. Bibcode:1998PNAS...95.1950E. doi:10.1073/pnas.95.4.1950. PMC 19220. PMID 9465123. Essigmann B, Hespenheide BM, Kuhn LA, Benning C (1999). "Prediction of the active-site structure and NAD(+) binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis". Arch. Biochem. Biophys. 369 (1): 30–41. doi:10.1006/abbi.1999.1344. PMID 10462438. Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C (2001). "Recombinant Arabidopsis SQD1 converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro". J. Biol. Chem. 276 (6): 3941–6. doi:10.1074/jbc.M008200200. PMID 11073956.
