biology

WBP11

WBP11 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand WBP11 rather than just read about it. In short: Alternative names WW domain binding protein 11 (WBP11) Npw38-binding protein (NpwBP) Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1) SH3 domain binding Protein, 70 kDa (SNP70) Function Studies suggest that Wbp11 plays a role in DNA/ RNA transcriptional or post-transcriptional events related to cell division. Wbp11 is found in the nucleus but not the nucleoli of cells in interphase.

Key takeaways

WBP11 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect WBP11 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of WBP11 from memory before moving on to harder problems.

Reference excerpt

Alternative names WW domain binding protein 11 (WBP11) Npw38-binding protein (NpwBP) Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1) SH3 domain binding Protein, 70 kDa (SNP70)

Function Studies suggest that Wbp11 plays a role in DNA/ RNA transcriptional or post-transcriptional events related to cell division. Wbp11 is found in the nucleus but not the nucleoli of cells in interphase. However it is distributed throughout the cytoplasm in dividing cells. Immunoelectron-microscopy experiments suggest that relocation from a peri-nuclear to a cytoplasmic distribution, coinciding with the onset of mitosis in cell division. Other studies have shown that Wbp11 is a component of the spliceosome. Also, that Wbp11 fragments block pre-mRNA splicing catalysis.

Protein interactions Wbp11 is a polypeptide known to interact with other WW domain of proteins such as the nuclear protein Npw38 via two proline-rich regions. It associates with Npw38 (hence the name NpwBP) in the nuclei and with Poly(rG) and G-rich ssDNA. The 70kDa protein has also been found to interact with SH3 (Src homology domain 3) domains. The C-terminal proline-rich sequences of SNP70/NpwBP/Wbp11, which binds to the WW domain of Npw38 also fits with both classic type I and type II SH3 binding sequences, hence the name (SNP70). Wbp11 was found to bind strongly to the tandem SH3 domains of p47phox and to the N-terminal SH3 domain of p47phox, and more weakly to the SH3 domains from c-src and p85α. p47phox. Furthermore, it has been shown to interact with PP1(protein phosphotase 1), hence the name SIPP1. It has an inhibitory effect to PP1, with its inhibitory potency increasing upon phosphorylation with protein kinase CK1. The binding of Wbp11 with PP1 involves a RVXF (Arg-Val-Xaa-Phe) motif, which functions as a PP1- binding sequence in most interactors of PP1. A number of other interactions have been indicated such as:

Vimentin Growth factor receptor-bound protein 2 (GRB2) Genome polyprotein Tyrosine-protein kinase Fyn Pre-mRNA-processing factor 39 (PRP39) TNF receptor-associated factor 4 (TRAF4) Calcineurin B homologous protein 3 (TESC) Probable ATP-dependent RNA helicase DDX17 CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) Poly(rC)-binding protein 1 (PCBP1)

References

Illustrations

Worked examples

Example 1 — a first encounter with WBP11

Start with the simplest possible case. Write down what WBP11 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to WBP11 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about WBP11 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of WBP11

In research: WBP11 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses WBP11 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: WBP11 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 12, Protein families, Protein stubs, so understanding it makes those chapters shorter.
In everyday life: Look for WBP11 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study WBP11 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what WBP11 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain WBP11 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is WBP11 in simple terms?

Alternative names WW domain binding protein 11 (WBP11) Npw38-binding protein (NpwBP) Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1) SH3 domain binding Protein, 70 kDa (SNP70) Function Studies suggest that Wbp11 plays a role in DNA/ RNA transcriptional or post-transcriptional events rela…

Why does WBP11 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study WBP11?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on WBP11.