biology

WDR62

WDR62 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand WDR62 rather than just read about it. In short: WD repeat-containing protein 62 is a protein that in humans is encoded by the WDR62 gene. Function WDR62 is a scaffold protein and interacts with different kinases.

Key takeaways

WDR62 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect WDR62 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of WDR62 from memory before moving on to harder problems.

Reference excerpt

WD repeat-containing protein 62 is a protein that in humans is encoded by the WDR62 gene.

Function WDR62 is a scaffold protein and interacts with different kinases. WDR62 plays a role in mediating activation of the JNK pathway in response to TNFα. This finding might have implications in the research of TNFα related diseases such as autoimmune diseases and cancer. It has been also shown that WDR62 upregulation can lead to overproliferation of glia cells and potentially glioma and this is coupled with an upregulation in AURKA, AKT, MYC and PI3K signalling. WDR62 effect on neurogenesis is regulated by MEKK3 in coordination with FBW7 (F-box and WD repeat domain-containing protein 7). WDR62 has been shown to have a regulatory role on hippocampus development and neurogenesis. WDR62 is also involved in male spermatogenesis with an essential role in centriole duplication and manchette removal during the spermatogenesis process. The deficiency of WDR62 results in low sperm counts with defected motility, and abnormal morphology.

Clinical significance Mutations in the WDR62 gene cause of a wide spectrum of severe cerebral cortical malformations including microcephaly, pachygyria with cortical thickening, hypoplasia of the corpus callosum, polymicrogyria as well as microlissencephaly. Cortical malformation, associated with WDR62 point mutations occurring in humans (V65M and R438H) has been linked to ciliopathies. These WDR62 point mutations drive ciliary disruption in Radial glial cell via disrupting the cilia and centrosome localization of CENPJ and the Intraflagellar transport protein 88 (IFT88), which are required for tubulin requitment to centrosome and transport of tubulin to the cilia tip, respectively.

References

Illustrations

Worked examples

Example 1 — a first encounter with WDR62

Start with the simplest possible case. Write down what WDR62 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to WDR62 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about WDR62 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of WDR62

In research: WDR62 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses WDR62 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: WDR62 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 19, Human chromosome 19 gene stubs, so understanding it makes those chapters shorter.
In everyday life: Look for WDR62 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “WDR62” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study WDR62 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what WDR62 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain WDR62 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is WDR62 in simple terms?

WD repeat-containing protein 62 is a protein that in humans is encoded by the WDR62 gene. Function WDR62 is a scaffold protein and interacts with different kinases.

Why does WDR62 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study WDR62?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on WDR62.