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Woolly monkey sarcoma virus

Woolly monkey sarcoma virus is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Woolly monkey sarcoma virus rather than just read about it. In short: Woolly monkey sarcoma virus (WMSV), with synonym Simian sarcoma virus (often abbreviated by SSV, but this may also stand for some species called Sulfolobus spindle-shaped virus, that belong to different genera in family Fuselloviridae) is a species of gammaretrovirus that infects primates. First isolation was from a fibrosarcoma in a woolly monkey (Lagothrix lagothrica).

Key takeaways

  • Woolly monkey sarcoma virus belongs to science; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect Woolly monkey sarcoma virus to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of Woolly monkey sarcoma virus from memory before moving on to harder problems.

Reference excerpt

Woolly monkey sarcoma virus (WMSV), with synonym Simian sarcoma virus (often abbreviated by SSV, but this may also stand for some species called Sulfolobus spindle-shaped virus, that belong to different genera in family Fuselloviridae) is a species of gammaretrovirus that infects primates. First isolation was from a fibrosarcoma in a woolly monkey (Lagothrix lagothrica). For its reproduction the virus needs a helper or associated virus which is called Simian sarcoma associated virus (SSAV), also known as woolly monkey virus (WMV). The WMSV/SSV genome is nearly identical to the WMV/SSAV genome, except the part corresponding to the env gene on the WMV/SSAV genome is replaced by an oncogene called p28/v-sis. The lack of an env renders it reliant on the SSAV for reproduction while the presence of the oncogene makes it sarcoma-causing. v-sis is derived from a primate PDGFB (c-sis) gene that the ancestral WMSV/SSV had picked up instead of its own env gene.

Simian sarcoma associated virus WMV/SSAV is its own independently-replicating retrovirus. It is usually lumped into the same species as the gibbon ape leukemia virus (GALV). It was originally detected in woolly monkeys co-housed in the same cage as gibbons, so the detection may have been due to a gibbon-to-monkey transmission rather than indicating the true natural host of the virus. Cladistically, the WMV/SSAV branch of the GALV-WMV clade also includes many rodent virues, including the Melomys burtoni retrovirus (MbRV), melomys woolly monkey retrovirus (MelWMV), and complete melomys woolly monkey retrovirus (cMWMV). cMWMV is a complete endogenous retrovirus found in some populations of Melomys leucogaster, still very capable of producing infectious virions, in contrast to earlier Melomys-harbored relatives which were incomplete.

See also HL23V

References

External links University of Massachusetts Medical School Umass Profiles: Sarcoma Virus, Woolly Monkey Born, M; von der Helm, K; Deinhardt, F (1982). "Virus-specific phosphoproteins in simian sarcoma virus-transformed primate cells". EMBO J. 1: 1029–33. doi:10.1002/j.1460-2075.1982.tb01291.x. PMC 553157. PMID 6329721. Johnsson, A; Betsholtz, C; Heldin, CH; Westermark, B (1986). "The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation". EMBO J. 5: 1535–41. doi:10.1002/j.1460-2075.1986.tb04394.x. PMC 1166977. PMID 3017700. Fidanián, HM; Drohán, WN; Baluda, MA (1975). "RNA of simian sarcoma-associated virus type 1 produced in human tumor cells". J Virol. 15: 449–57. doi:10.1128/JVI.15.3.449-457.1975. PMC 354479. PMID 46285. Wolfe, L. G.; Smith, R. K.; Deinhardt, F. (1972). "Simian Sarcoma Virus, Type 1 (Lagothrix): Focus Assay and Demonstration of Nontransforming Associated Virus". JNCI J Natl Cancer Inst. 48 (6): 1905–1908. doi:10.1093/jnci/48.6.1905.

Worked examples

Example 1 — a first encounter with Woolly monkey sarcoma virus

Start with the simplest possible case. Write down what Woolly monkey sarcoma virus claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Woolly monkey sarcoma virus before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Woolly monkey sarcoma virus ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Woolly monkey sarcoma virus

In research
Woolly monkey sarcoma virus appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses Woolly monkey sarcoma virus in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
Woolly monkey sarcoma virus is common in secondary-school and first-year university syllabi. It links to neighbouring topics Gammaretroviruses, Virus stubs, so understanding it makes those chapters shorter.
In everyday life
Look for Woolly monkey sarcoma virus outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study Woolly monkey sarcoma virus in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what Woolly monkey sarcoma virus means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain Woolly monkey sarcoma virus out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Woolly monkey sarcoma virus in simple terms?

Woolly monkey sarcoma virus (WMSV), with synonym Simian sarcoma virus (often abbreviated by SSV, but this may also stand for some species called Sulfolobus spindle-shaped virus, that belong to different genera in family Fuselloviridae) is a species of gammaretrovirus that infects primates. First is…

Why does Woolly monkey sarcoma virus matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Woolly monkey sarcoma virus?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Woolly monkey sarcoma virus.

Tags

  • Gammaretroviruses
  • Virus stubs

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