Woolly monkey sarcoma virus (WMSV), with synonym Simian sarcoma virus (often abbreviated by SSV, but this may also stand for some species called Sulfolobus spindle-shaped virus, that belong to different genera in family Fuselloviridae) is a species of gammaretrovirus that infects primates. First isolation was from a fibrosarcoma in a woolly monkey (Lagothrix lagothrica). For its reproduction the virus needs a helper or associated virus which is called Simian sarcoma associated virus (SSAV), also known as woolly monkey virus (WMV). The WMSV/SSV genome is nearly identical to the WMV/SSAV genome, except the part corresponding to the env gene on the WMV/SSAV genome is replaced by an oncogene called p28/v-sis. The lack of an env renders it reliant on the SSAV for reproduction while the presence of the oncogene makes it sarcoma-causing. v-sis is derived from a primate PDGFB (c-sis) gene that the ancestral WMSV/SSV had picked up instead of its own env gene.
Simian sarcoma associated virus WMV/SSAV is its own independently-replicating retrovirus. It is usually lumped into the same species as the gibbon ape leukemia virus (GALV). It was originally detected in woolly monkeys co-housed in the same cage as gibbons, so the detection may have been due to a gibbon-to-monkey transmission rather than indicating the true natural host of the virus. Cladistically, the WMV/SSAV branch of the GALV-WMV clade also includes many rodent virues, including the Melomys burtoni retrovirus (MbRV), melomys woolly monkey retrovirus (MelWMV), and complete melomys woolly monkey retrovirus (cMWMV). cMWMV is a complete endogenous retrovirus found in some populations of Melomys leucogaster, still very capable of producing infectious virions, in contrast to earlier Melomys-harbored relatives which were incomplete.
See also HL23V
References
External links University of Massachusetts Medical School Umass Profiles: Sarcoma Virus, Woolly Monkey Born, M; von der Helm, K; Deinhardt, F (1982). "Virus-specific phosphoproteins in simian sarcoma virus-transformed primate cells". EMBO J. 1: 1029–33. doi:10.1002/j.1460-2075.1982.tb01291.x. PMC 553157. PMID 6329721. Johnsson, A; Betsholtz, C; Heldin, CH; Westermark, B (1986). "The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation". EMBO J. 5: 1535–41. doi:10.1002/j.1460-2075.1986.tb04394.x. PMC 1166977. PMID 3017700. Fidanián, HM; Drohán, WN; Baluda, MA (1975). "RNA of simian sarcoma-associated virus type 1 produced in human tumor cells". J Virol. 15: 449–57. doi:10.1128/JVI.15.3.449-457.1975. PMC 354479. PMID 46285. Wolfe, L. G.; Smith, R. K.; Deinhardt, F. (1972). "Simian Sarcoma Virus, Type 1 (Lagothrix): Focus Assay and Demonstration of Nontransforming Associated Virus". JNCI J Natl Cancer Inst. 48 (6): 1905–1908. doi:10.1093/jnci/48.6.1905.
