chemistry

Xaliproden

Xaliproden is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Xaliproden rather than just read about it. In short: Xaliproden (developmental code names SR-57746 and SR-57746A) is a serotonin 5-HT1A receptor agonist which was under development for the treatment of Alzheimer's disease, amyotrophic lateral sclerosis (ALS), cancer pain, and multiple sclerosis but was never marketed. It is taken orally.

Key takeaways

Xaliproden belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Xaliproden to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Xaliproden from memory before moving on to harder problems.

Reference excerpt

Xaliproden (developmental code names SR-57746 and SR-57746A) is a serotonin 5-HT1A receptor agonist which was under development for the treatment of Alzheimer's disease, amyotrophic lateral sclerosis (ALS), cancer pain, and multiple sclerosis but was never marketed. It is taken orally. The drug acts as a selective and potent full agonist of the serotonin 5-HT1A receptor. However, it also shows much lower affinity for sigma receptors. Xaliproden produces neurotrophic and neuroprotective effects in preclinical research. It also fully substitutes for the serotonin 5-HT1A receptor full agonist 8-OH-DPAT in rodent drug discrimination tests and produces antidepressant-like, anxiolytic-like, antiaggressive, and analgesic effects in rodents. The drug efficiently crosses the blood–brain barrier in rodents. Side effects of xaliproden in humans include diarrhea, nausea, vomiting, insomnia, dizziness, vertigo, asthenia or fatigue, paresthesia, tinnitus, and anxiety. Development of xaliproden for Alzheimer's disease and ALS was discontinued in 2007 following analysis of Phase III data. In addition development for cancer pain was discontinued in 2009. The drug showed an effect on hippocampal volume that suggested slowing of atrophy in clinical trials of people with Alzheimer's disease. However, there was insufficient clinical evidence for effectiveness in counteracting Alzheimer's disease-related cognitive decline. Similarly, while there were some indicators of effectiveness in ALS, including a small but clinically noteworthy effect on some functional parameters, the overall benefit did not reach statistical significance when results across several Phase III trials were averaged. Paliroden (SR-57667; SR-57667B), an analogue of xaliproden, was also investigated for treatment of Alzheimer's disease and Parkinson's disease, and reached phase 2 trials for these indications, but development was likewise discontinued.

See also Substituted naphthylethylamine Cyclized phenethylamine Paliroden

References

Illustrations

Worked examples

Example 1 — a first encounter with Xaliproden

Start with the simplest possible case. Write down what Xaliproden claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Xaliproden before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Xaliproden ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Xaliproden

In research: Xaliproden appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Xaliproden in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Xaliproden is common in secondary-school and first-year university syllabi. It links to neighbouring topics 2-Naphthyl compounds, 3-(Trifluoromethyl)phenyl compounds, 5-HT1A agonists, so understanding it makes those chapters shorter.
In everyday life: Look for Xaliproden outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Xaliproden in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Xaliproden means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Xaliproden out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Xaliproden in simple terms?

Why does Xaliproden matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Xaliproden?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Xaliproden.