chemistry

Z8526711350

Z8526711350 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Z8526711350 rather than just read about it. In short: Z8526711350 (also known as '1350 or YVF) is a synthetic cannabinoid from the pyrazolecarboxamide family. It was developed using an ultra-large-scale docking approach to screen a library of 12 billion molecules and then dock 74 million of these against an in silico model of the CB1 receptor, of which the most promising 60 hits were prioritised for synthesis. 46 molecules were successfully made, of which 9 proved to s…

Key takeaways

Z8526711350 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Z8526711350 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Z8526711350 from memory before moving on to harder problems.

Reference excerpt

Z8526711350 (also known as '1350 or YVF) is a synthetic cannabinoid from the pyrazolecarboxamide family. It was developed using an ultra-large-scale docking approach to screen a library of 12 billion molecules and then dock 74 million of these against an in silico model of the CB1 receptor, of which the most promising 60 hits were prioritised for synthesis. 46 molecules were successfully made, of which 9 proved to show significant affinity to CB1 and two of these were found to be active as CB1 agonists with suitable solubility properties for further testing. Of these, ZINC537551486 was found to have a binding affinity of 731 nM at CB1 and was selected for further synthetic elaboration. After two rounds of synthetic modification for increased potency, the active enantiomer Z8526711350 was found to have a CB1 affinity of 0.95 nM, which made it stronger than the reference agonist CP 55,940 used for the docking studies. Z8526711350 was found to be a potent analgesic in animal models and also showed efficacy against allodynia caused by nerve damage, suggesting potential applications for the treatment of neuropathic pain. However, it is also believed to show functional selectivity as it showed reduced levels of sedation and of other animal surrogates of psychoactive effects.

See also 5F-AB-FUPPYCA Tedalinab Z3517967757 Z0443438219

References

Illustrations

Worked examples

Example 1 — a first encounter with Z8526711350

Start with the simplest possible case. Write down what Z8526711350 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Z8526711350 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Z8526711350 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Z8526711350

In research: Z8526711350 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Z8526711350 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Z8526711350 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 3-(Trifluoromethyl)phenyl compounds, Cannabinoid stubs, Cannabinoids, so understanding it makes those chapters shorter.
In everyday life: Look for Z8526711350 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Z8526711350 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Z8526711350 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Z8526711350 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Z8526711350 in simple terms?

Why does Z8526711350 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Z8526711350?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Z8526711350.