astronomy

Ze'ev Ronai

Ze'ev Ronai is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Ze'ev Ronai rather than just read about it. In short: Ze’ev Ronai (Hebrew: זאב רונאי) is an Israeli-American cancer research scientist and Director of the Institute for Translational Research at Cedars Sinai Medical Center in Los Angeles, US. Education Ze’ev Ronai was born in Haifa in 1956.

Key takeaways

Ze'ev Ronai belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Ze'ev Ronai to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Ze'ev Ronai from memory before moving on to harder problems.

Reference excerpt

Ze’ev Ronai (Hebrew: זאב רונאי) is an Israeli-American cancer research scientist and Director of the Institute for Translational Research at Cedars Sinai Medical Center in Los Angeles, US.

Education Ze’ev Ronai was born in Haifa in 1956. He attended Hugim High School in Haifa, and received his B.S. (Biology) and Ph.D. (Immunology) from the Hebrew University of Jerusalem.

Research Ronai's studies provide new fundamental understanding for the role and function of epigenetic components (transcription factor and ubiquitin ligases) in cancer. Early in his career he developed a sensitive PCR approach to detect mutant Ras oncogene in normal appearing tissues. Later on, his studies provided the foundation for the rewired signaling in cancer, by demonstrating the important role of protein subcellular localization in its oncogenic function and by establishing the function of ubiquitin ligases in key cellular processes (i.e. hypoxia, unfolded protein response, mitochondrial dynamics, anti-tumor immunity) and their critical contribution to development, progression, and therapy resistance of prostate and breast cancers and melanoma. He developed SBI-756, a small molecule inhibitor, which targets the translation initiation complex, inhibiting melanoma and lymphoid tumors. Ze’ev Ronai published close to 300 peer-reviewed publications, reflected in over 20,000 citations. Following post doctoral training with I.B. Weinstein at Columbia University, Ronai began his independent career on the campus of the New York Medical College, followed by tenure at Mount Sinai School of Medicine in NY. He joined Sanford Burnham Prebys Medical Discovery Institute in 2004 where he served as Program Director, Scientific Director, Deputy and later the Director of the NCI designated basic cancer center. In 2024 he relocated to Cedars Sinai in LA, where he establishes the Institute for Translational Research. In Israel, he has established the Technion Integrated Cancer Center, (with the Nobel Laureate Aaron Ciechanover), first in class where engineers biologists and oncologists collaborate to defeat cancer.

Awards and honors Ronai received the Lifetime Achievement Award from the Society for Melanoma Research (2016). Earlier, he obtained the Golda Meir Fellowship from the Hebrew University. He also served as editor in chief of Pigment Cell & Melanoma Research.

Patents Ronai obtained a number patents for his inventions; those include a "Quantitative method for early detection of mutant alleles and diagnostic kits for carrying out the method" (1996), "Inhibition of ATF2 activity to treat cancer" (2011), and "Compositions and methods for inhibiting growth and metastasis of melanoma" (2011).

Publications (>300, with >33,000 citations) Kahn, S.M., Jiang, W., Culbertson, T.A., Weinstein, I.B. Williams, G.M., Ronai, Z. Rapid and sensitive nonradioactive detection of mutant K-ras genes via ‘enriched’ PCR amplification. Oncogene. 6(6):1079-83, 1991. Tobi, M., Luo, F.C., Ronai, Z. Detection of K-ras mutation in colonic effluent samples from patients without evidence for colorectal carcinoma. J Natl Cancer Inst. 86(13):1007-10, 1994. Fuchs, S.Y., Dolan, L.R., Davis, R., Ronai, Z. Phosphorylation dependent targeting of c-Jun ubiquitination by Jun N-kinase. Oncogene. 13(7):1531-5, 1996. Adler, V., Yin, Z., Fuchs, S.Y., Benezra, M., Rosario, L., Tew, K.D., Pincus, M.R., Sardana, M., Henderson, C.J., Wolf, C.R., Davis, R. Ronai, Z. Regulation of JNK signaling by GSTp. EMBO J. 18:1321-34, 1999. Habelhah, H., Shah, K., Hunag, L., Ostareck-Lederer. A., Burlingame, A.L., Shokat, K.M., Hentze, M.W., Ronai, Z. ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol. 3(3):325-30, 2001. Bhoumik, A., Jones, N., Ronai, Z. Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity. Proc Natl Acad Sci U S A. 101(12):4222-7, 2004. Nakayama, K., Frew, I.J., Hagensen, M., Skals, M., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument-Bromage, H., Tempst, P., Frappell, P.B., Bowtell, D.D., Ronai, Z. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell. 117(7):941-52, 2004.

Personal life Ze’ev Ronai is married to Iris Ronai (1980); they have three children.

References

External links Ze’ev Ronai lab page is www.ronailab.net

Worked examples

Example 1 — a first encounter with Ze'ev Ronai

Start with the simplest possible case. Write down what Ze'ev Ronai claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Ze'ev Ronai before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Ze'ev Ronai ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Ze'ev Ronai

In research: Ze'ev Ronai appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Ze'ev Ronai in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Ze'ev Ronai is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1956 births, Cancer researchers, Hebrew University of Jerusalem alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Ze'ev Ronai outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Ze'ev Ronai in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Ze'ev Ronai means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Ze'ev Ronai out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Ze'ev Ronai in simple terms?

Ze’ev Ronai (Hebrew: זאב רונאי) is an Israeli-American cancer research scientist and Director of the Institute for Translational Research at Cedars Sinai Medical Center in Los Angeles, US. Education Ze’ev Ronai was born in Haifa in 1956.

Why does Ze'ev Ronai matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Ze'ev Ronai?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Ze'ev Ronai.