chemistry

Zhu Jieping

Zhu Jieping is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Zhu Jieping rather than just read about it. In short: Jieping Zhu (祝介平; born 1965 in Xiaoshan, Hangzhou, China) is an organic chemist specializing in natural product total synthesis and organometallics. He is a professor of chemistry at EPFL (École Polytechnique Fédérale de Lausanne) and the head of the Laboratory of Synthesis and Natural Products.

Key takeaways

Zhu Jieping belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Zhu Jieping to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Zhu Jieping from memory before moving on to harder problems.

Reference excerpt

Jieping Zhu (祝介平; born 1965 in Xiaoshan, Hangzhou, China) is an organic chemist specializing in natural product total synthesis and organometallics. He is a professor of chemistry at EPFL (École Polytechnique Fédérale de Lausanne) and the head of the Laboratory of Synthesis and Natural Products.

Career Zhu studied chemistry at Hangzhou Normal University and at Lanzhou University, both in China. He then joined Henri-Philippe Husson and Jean-Charles Quirion to pursue a PhD in organic chemistry at the Institute de Chimie des Substances Naturelles at the French National Centre for Scientific Research. In 1991, he graduated with a thesis on Synthèse asymétrique de dérivés de l'histrionicotoxine et de spiropipéridines apparentées (Asymmetric synthesis of histrionicotoxin derivatives and related spiropiperidines). As a postdoctoral researcher he went to work with Derek Barton at the Texas A&M University and pursue research on phosphonic acid synthesis. In 1992, he joined Institut de Chimie des Substances Naturelles (ICSN) as a chargé de recherche. In 2000, he was promoted to directeur de recherche 2nd class, then 1st class in 2006 in the same institute. Since 2010, he has been full professor of chemistry at EPFL's School of Basic Sciences of EPFL.

Research Zhu's research focuses on the development of new synthetic methods including multicomponent reactions, catalytic enantioselective transformations, and transition metal catalyzed domino processes. He is also immersed in the total synthesis of complex natural products and bioactive molecules.

Distinctions Zhu is the recipient of among others the 2016 Natural Product Chemistry Award from the Royal Society of Chemistry (RSC) Natural Product Chemistry Award, the 2010 Division of Organic Chemistry (Prix SCF-DCO) award from the Société chimique de France (French Chemical Society), the 2009 Chang Jiang Scholars (Qinghua University) awarded by the Chinese Ministry of Education, the 2009 Silver Medal of CNRS, the 2008 Novartis Chemistry Lectureship, the 2004 Liebig Lectureship of the German Chemical Society, and the 2003 Prix “Emile Jungfleisch” of French Academy of Science. He is a fellow of the Royal Society of Chemistry. He is editor at the journal Tetrahedron Letters.

Selected works

Books Zhu, Jieping; Bienaymé, Hugues (6 March 2006). Multicomponent Reactions. John Wiley & Sons. ISBN 9783527604241. Zhu, Jieping; Wang, Qian; Wang, Meixiang (15 October 2014). Multicomponent Reactions in Organic Synthesis. John Wiley & Sons. ISBN 9783527678204.

Papers Zhu, Jieping (2003). "Recent Developments in the Isonitrile-Based Multicomponent Synthesis of Heterocycles". European Journal of Organic Chemistry. 2003 (7): 1133–1144. doi:10.1002/ejoc.200390167. Janvier, Pierre; Sun, Xiaowen; Bienaymé, Hugues; Zhu, Jieping (2002). "Ammonium Chloride-Promoted Four-Component Synthesis of Pyrrolo[3,4-b]pyridin-5-one". Journal of the American Chemical Society. 124 (11): 2560–2567. Bibcode:2002JAChS.124.2560J. doi:10.1021/ja017563a. PMID 11890807. Chen, Jinchun; Chen, Xiaochuan; Bois-Choussy, Michèle; Zhu, Jieping (2006). "Total Synthesis of Ecteinascidin 743". Journal of the American Chemical Society. 128 (1): 87–89. Bibcode:2006JAChS.128...87C. doi:10.1021/ja0571794. PMID 16390134. Xu, Zhengren; Wang, Qian; Zhu, Jieping (2015). "Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine e, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines a and C". Journal of the American Chemical Society. 137 (20): 6712–6724. Bibcode:2015JAChS.137.6712X. doi:10.1021/jacs.5b03619. PMID 25946614. Andres, Rémi; Wang, Qian; Zhu, Jieping (2020). "Asymmetric Total Synthesis of (−)-Arborisidine and (−)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet–Spengler Reaction". Journal of the American Chemical Society. 142 (33): 14276–14285. Bibcode:2020JAChS.14214276A. doi:10.1021/jacs.0c05804. PMID 32692169. S2CID 220672260. Delayre, Bastien; Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2020). "Ti Cl 3 -Mediated Synthesis of 2,3,3-Trisubstituted Indolenines: Total Synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline, and (−)-Tubifoline". Angewandte Chemie International Edition. 59 (33): 13990–13997. doi:10.1002/anie.202005380. PMID 32415682. S2CID 218657815.

References

External links Zhu Jieping publications indexed by Google Scholar Website of the Laboratory of Synthesis and Natural Products

Illustrations

Worked examples

Example 1 — a first encounter with Zhu Jieping

Start with the simplest possible case. Write down what Zhu Jieping claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Zhu Jieping before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Zhu Jieping ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Zhu Jieping

In research: Zhu Jieping appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Zhu Jieping in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Zhu Jieping is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1965 births, Academic staff of the École Polytechnique Fédérale de Lausanne, French organic chemists, so understanding it makes those chapters shorter.
In everyday life: Look for Zhu Jieping outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Zhu Jieping in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Zhu Jieping means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Zhu Jieping out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Zhu Jieping in simple terms?

Why does Zhu Jieping matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Zhu Jieping?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Zhu Jieping.